Treatment Options for Chronic Lymphocytic Leukemia: A Patient's Guide - Oncology

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Chronic Lymphocytic Leukemia (CLL) is a type of cancer that affects the blood and bone marrow. It is characterized by the accumulation of abnormal lymphocytes, a type of white blood cell, which can interfere with the production of normal blood cells. CLL typically progresses slowly and may not cause symptoms in the early stages. Common symptoms,


I am a family member of a patient.
I would like to ask the doctor about the medication for chronic lymphocytic leukemia (CLL) patients that is not effectively controlling the condition.
The hospital physician mentioned a certain injection that costs 60,000 NT dollars, which is not covered by health insurance.
What is the purpose of this injection, and should we continue with it?

lkk, 60~69 year old female. Ask Date: 2008/04/30

Dr. Fan Sheng reply Oncology


LKK: It is a monoclonal antibody that can target chronic lymphocytic leukemia.
It may be more appropriate to discuss the potential benefits and side effects of this therapy with your doctor.

Reply Date: 2008/04/30

More Info


Chronic Lymphocytic Leukemia (CLL) is a type of cancer that affects the blood and bone marrow, characterized by the accumulation of abnormal lymphocytes. Treatment options for CLL vary based on several factors, including the stage of the disease, the patient's overall health, and how well the disease responds to initial treatments.
In cases where standard oral medications or chemotherapy do not adequately control the disease, healthcare providers may recommend additional therapies, including monoclonal antibodies or targeted therapies. One such treatment that you mentioned is an injectable medication that costs around 60,000 NT dollars and is not covered by health insurance. This type of medication is often a monoclonal antibody, such as Rituximab or Obinutuzumab, which targets specific proteins on the surface of cancer cells, helping the immune system to recognize and destroy them.

The decision to continue with such an expensive treatment should be made after careful consideration of several factors:
1. Efficacy: It is essential to discuss with the treating physician the expected benefits of the injection. How effective has it been in similar cases? What are the chances that it will help control the disease in your specific situation?
2. Side Effects: All treatments come with potential side effects. Understanding the risks associated with the injection is crucial. Are there any serious side effects that could impact the patient's quality of life?
3. Alternative Treatments: Are there other treatment options available that may be more effective or less expensive? For example, newer oral agents like ibrutinib or venetoclax have shown promise in treating CLL and may be covered by insurance.

4. Financial Considerations: The cost of treatment can be a significant burden. If the injection is deemed necessary, it may be worth discussing financial assistance programs with the hospital or exploring clinical trials that may offer the treatment at no cost.

5. Quality of Life: Ultimately, the goal of treatment is to improve the patient's quality of life. If the injection is likely to provide a better quality of life or prolong survival, it may be worth the investment.

6. Consultation with Specialists: If there are uncertainties about the treatment plan, seeking a second opinion from another hematologist or oncologist specializing in CLL can provide additional insights and options.

In summary, while the injectable medication may offer potential benefits, it is crucial to weigh these against the costs and possible side effects. Open communication with the healthcare team is vital to make an informed decision that aligns with the patient's treatment goals and financial situation. Always remember that the patient's well-being and preferences should be at the forefront of any treatment decision.

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