Issues Regarding Adult Vaccination for Japanese Encephalitis
Hello, Doctor! I have a question.
I received the varicella vaccine in early April.
When can I conceive? Is it three months or six months? If I accidentally become pregnant after receiving the varicella vaccine, will it affect the fetus? Thank you for your response!
Xiao Mei, 20~29 year old female. Ask Date: 2008/08/22
Dr. Huang Jianxun reply Obstetrics and Gynecology
In principle, it is recommended to avoid pregnancy for three months after receiving the varicella vaccine.
If a woman accidentally becomes pregnant after vaccination, will it affect the fetus? Recent literature provides reference: J Infect Dis.
2008 Mar 1;197 Suppl 2:S178-84.
"Varicella vaccine exposure during pregnancy: data from 10 Years of the pregnancy registry." Wilson E, Goss MA, Marin M, Shields KE, Seward JF, Rasmussen SA, Sharrar RG.
Clinical Risk Management and Safety Surveillance, Merck & Co., Inc., West Point, Pennsylvania, USA.
[email protected].
BACKGROUND: The Pregnancy Registry for Varivax (Merck) was established to monitor for congenital varicella syndrome or other birth defects in the offspring of women who were exposed to the varicella vaccine while pregnant.
METHODS: The registry receives voluntary reports from healthcare providers or consumers about women who received the vaccine three months before or during pregnancy.
Follow-up is conducted to obtain and classify pregnancy outcomes.
All reports are evaluated for the presence of birth defects.
Outcomes from prospectively reported pregnancy exposures are used to calculate rates and 95% confidence intervals.
RESULTS: From March 17, 1995, through March 16, 2005, 981 women were enrolled.
Pregnancy outcomes were available for 629 prospectively enrolled women.
Among the 131 live births to varicella-zoster virus-seronegative women, there was no evidence of congenital varicella syndrome (rate, 0% [95% confidence interval [CI], 0%-6.7%]), and major birth defects were observed in 3 infants (rate, 3.7% [95% CI, 0.8%-10.7%]).
CONCLUSIONS: Although the number of exposures is not sufficient to rule out a very low risk, data collected in the pregnancy registry to date do not support a relationship between the occurrence of congenital varicella syndrome or other birth defects and varicella vaccine exposure during pregnancy.
Reply Date: 2008/08/22
More Info
When considering pregnancy after receiving the varicella (chickenpox) vaccine, it is essential to understand the recommendations and potential implications for both the mother and the fetus. The varicella vaccine is a live attenuated vaccine, which means it contains a weakened form of the varicella-zoster virus. This vaccine is effective in preventing chickenpox, but it also raises questions about its safety in relation to pregnancy.
According to health guidelines, it is generally recommended that women avoid becoming pregnant for at least three months after receiving the varicella vaccine. This recommendation is based on the understanding that while the risk is low, there is a theoretical concern regarding the potential for the live virus to affect a developing fetus. The three-month waiting period allows sufficient time for the vaccine to be cleared from the body, minimizing any risk to a future pregnancy.
If a woman inadvertently becomes pregnant shortly after receiving the varicella vaccine, the available data suggests that the risk of adverse effects on the fetus is very low. A study published in the Journal of Infectious Diseases analyzed data from a pregnancy registry for women who received the varicella vaccine either three months before or during pregnancy. The findings indicated that there was no evidence of congenital varicella syndrome or other significant birth defects associated with exposure to the vaccine during pregnancy. Specifically, among the women who were seronegative for the varicella-zoster virus and had live births, the rate of congenital varicella syndrome was found to be 0%, and major birth defects were observed in only a small percentage of cases.
In summary, while it is advisable to wait at least three months after receiving the varicella vaccine before attempting to conceive, the risk of fetal harm from unintentional pregnancy shortly after vaccination appears to be minimal based on current evidence. However, it is always best to consult with a healthcare provider for personalized advice, especially if there are any concerns or specific health conditions involved.
In addition to the considerations regarding the varicella vaccine, it is also important for pregnant women to be aware of their immunity status regarding chickenpox. Women who have had chickenpox in the past typically have immunity and are less likely to contract the virus again, which provides some protection for the fetus. However, if a pregnant woman has not had chickenpox or has not been vaccinated, she may be at risk if exposed to someone with the virus. In such cases, it is advisable to discuss vaccination options and potential exposure risks with a healthcare provider.
Overall, understanding the implications of vaccination and pregnancy is crucial for ensuring the health and safety of both the mother and the baby. Regular prenatal care and open communication with healthcare professionals can help manage any concerns and provide guidance throughout the pregnancy journey.
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