Yellow Eyes: Causes, Concerns, and Treatment Options - Family Medicine

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Could you please provide more details about your eye condition?


Since elementary school, my eyes have been yellowish, and I also have nasal allergies.
Every morning when I wake up, my eyes are very red, making them look quite alarming.
This summer, I went to a large hospital for an examination.
After a blood test, the doctor informed me that my bilirubin levels were indeed elevated, but my liver function tests were normal.
He prescribed a medication called "Ursodeoxycholic Acid" for me.
After my follow-up examination, he told me that my bilirubin levels had returned to normal and advised me not to worry too much.
It's been almost a month since then, and I haven't paid close attention to whether there's been any improvement, but my eyes are still yellowish.
Is it possible that my bilirubin levels have risen again? I'm quite anxious because yellow eyes are really unattractive, and everyone who doesn't know me keeps asking about it.

Xiao Cai, 10~19 year old female. Ask Date: 2008/09/10

Dr. Lai Junlong reply Family Medicine


Hello: I would like to respond as follows: The yellowing of the eyes may need to be differentiated between conjunctival hyperemia (the so-called "whites of the eyes") due to vascular dilation and true jaundice.
As we are of Asian descent, the deposition of pigment cells and pigments on the surface of the skin can manifest as a yellow color.
Additionally, if blood is drawn on an empty stomach, the gallbladder may not have emptied bile, leading to decreased bile metabolism, which can cause slightly elevated bilirubin levels (both Total and Direct bilirubin) in the blood.
Generally, a total bilirubin level not exceeding 2.5 mg/dL will not cause true jaundice in the sclera.
Your allergic rhinitis may impede the circulation of blood and tears in the eyes, resulting in congestion of the microvasculature within the eyeball.
Over time, some pigment deposition may cause the sclera to appear yellow, which could be mistaken for true jaundice.
Qushuchun is a basic anion exchange resin (cholestyramine) used to promote bile acid metabolism and subsequently lower cholesterol levels in the blood.
By promoting bile acid metabolism, it indirectly reduces bilirubin levels, leading to a decrease in jaundice indices.
I recommend that you consult a specialist in hepatobiliary gastroenterology or family medicine for a thorough evaluation and blood tests to determine the underlying cause and appropriate treatment.
Thank you.
Dr.
Lai Junlong

Reply Date: 2008/09/10

More Info


Yellowing of the eyes, known as jaundice, is primarily caused by an excess of bilirubin in the bloodstream. Bilirubin is a yellow pigment that is produced during the breakdown of red blood cells. When the liver is functioning properly, it processes bilirubin and excretes it through bile. However, when there is a disruption in this process, bilirubin can accumulate, leading to the yellowing of the skin and the whites of the eyes (sclera).

In your case, you mentioned that you have had yellow eyes since elementary school, and recent tests showed elevated bilirubin levels, although your liver function tests were normal. This suggests that while your liver is functioning adequately, there may be other factors contributing to the elevated bilirubin levels. Conditions such as Gilbert's syndrome, a common and benign genetic condition, can lead to intermittent elevations in bilirubin without any significant liver dysfunction.
The medication you were prescribed, "Guishuchun," is likely aimed at addressing any underlying issues related to bilirubin metabolism. It is encouraging that your bilirubin levels returned to normal after treatment, but the persistence of yellowing in your eyes could be due to several reasons:
1. Residual Bilirubin: Even if your bilirubin levels are within the normal range, the sclera may take some time to return to its usual color, especially if the yellowing has been present for a long time.

2. Dietary Factors: Certain foods can influence the appearance of your eyes. For example, consuming foods high in carotenoids (like carrots and sweet potatoes) can sometimes impart a yellowish hue to the skin and eyes.

3. Allergies and Inflammation: You mentioned having nasal allergies, which can lead to eye redness and irritation. Allergic reactions can cause inflammation in the eyes, potentially making them appear more yellow or red.

4. Other Medical Conditions: While your liver function tests were normal, other conditions affecting the liver or bile ducts could still be at play. Conditions such as hemolytic anemia, where red blood cells are destroyed faster than they can be produced, can lead to increased bilirubin levels.

Given your concerns about the yellowing of your eyes, it is essential to follow up with your healthcare provider. They may recommend additional tests, such as imaging studies of the liver and bile ducts, or further blood tests to rule out any underlying conditions that could be contributing to your symptoms.
In the meantime, here are some general recommendations to consider:
- Regular Monitoring: Keep track of your bilirubin levels and liver function tests as advised by your doctor. Regular check-ups can help monitor any changes.

- Hydration and Diet: Ensure you stay well-hydrated and maintain a balanced diet rich in fruits, vegetables, and whole grains. This can support overall liver health.

- Avoid Alcohol and Toxins: Limit alcohol consumption and avoid exposure to toxins that can stress the liver.

- Manage Allergies: If you have allergies, consider discussing treatment options with your doctor to help reduce eye redness and irritation.

- Seek a Second Opinion: If you continue to feel anxious about your condition, it may be beneficial to seek a second opinion from a specialist, such as a hepatologist or an ophthalmologist, who can provide further insights into your symptoms.

In conclusion, while the yellowing of your eyes can be concerning, it is often manageable with proper medical guidance and lifestyle adjustments. Don't hesitate to reach out to your healthcare provider for reassurance and to address any ongoing concerns.

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