Persistent Cough After Chemotherapy: What to Do Next? - Oncology

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Why do patients experience persistent coughing after chemotherapy?


Doctor: Hello! I would like to ask you two questions.
My father received chemotherapy on October 20, and for some unknown reason, he has been experiencing persistent vomiting since then, almost without stopping, and he has some pain in his lower abdomen.
We are unsure what to do.
Seeing him in pain, how can we help him stop vomiting? Does this indicate a problem with his stomach, or could it be a side effect of the chemotherapy? (However, he didn't seem to have this issue in the past.) We would like to know what steps we should take.
Thank you! Additionally, my father is 78 years old and was diagnosed with colon cancer in 2004, which later metastasized to the liver.
In 2007, he underwent surgery due to perforations in the liver, stomach, and intestines caused by radiofrequency ablation of a liver tumor.
He is currently receiving targeted therapy and chemotherapy, but his tumor markers are rising.
We are unsure what to do.
My father has expressed a desire to stop treatment (as he has been undergoing chemotherapy since 2004), but we are concerned that not treating him will lead to worsening conditions.
Therefore, I would like to ask if it is the right decision for us to insist on him continuing chemotherapy.
Thank you!

Xiao Yu, 30~39 year old female. Ask Date: 2008/10/23

Dr. Fan Sheng reply Oncology


Xiao Yu: Some chemotherapeutic agents, like Irinotecan used for treating colorectal cancer, have been reported to cause coughing.
However, the commonly used antiemetic Dexamethasone during chemotherapy has a higher suspicion of causing coughing.
It is recommended to consult your father's attending physician to consider discontinuing Dexamethasone; perhaps the coughing will resolve.
Currently, there are two targeted therapy medications available; one is ineffective, so the other can be considered.
However, if tumor markers continue to rise, continuing chemotherapy may impair quality of life.
In such cases, adopting a palliative care approach may be more appropriate.

Reply Date: 2008/10/23

More Info


Dear Patient,
Thank you for reaching out with your concerns regarding your father's persistent cough and abdominal pain following chemotherapy. I understand how distressing this situation can be for both you and your father, especially given his medical history. Let’s address your questions one by one.


Persistent Cough After Chemotherapy
1. Understanding the Cough: A persistent cough after chemotherapy can arise from several factors. Chemotherapy can irritate the respiratory system, leading to inflammation and increased mucus production. Additionally, if your father has a history of lung issues or if he is undergoing targeted therapy, these could contribute to respiratory symptoms. It’s also possible that the cough is related to gastroesophageal reflux disease (GERD), which can be exacerbated by chemotherapy and can cause coughing due to acid irritating the throat.

2. Management Strategies: To alleviate the cough, consider the following approaches:
- Hydration: Encourage your father to drink plenty of fluids. Staying hydrated can help thin mucus, making it easier to expel.

- Humidifier: Using a humidifier in his room can help keep the air moist, which may soothe his throat and reduce coughing.

- Cough Suppressants: Over-the-counter cough syrups may provide temporary relief. However, consult his healthcare provider before administering any medication.

- Positioning: Elevating his head while sleeping can help reduce coughing at night.

3. When to Seek Medical Attention: If the cough persists or worsens, or if he experiences additional symptoms such as fever, shortness of breath, or chest pain, it’s crucial to contact his healthcare provider. They may recommend further evaluation, such as imaging studies or pulmonary function tests, to rule out any serious complications.


Abdominal Pain
1. Possible Causes: The abdominal pain could be related to several factors, including:
- Chemotherapy Side Effects: Some chemotherapy agents can cause gastrointestinal discomfort, nausea, or changes in bowel habits.

- Previous Surgeries: Given your father's history of surgeries for bowel perforation, there may be adhesions or other complications contributing to his pain.

- Liver Function: Since he has a history of liver metastasis, it’s essential to monitor liver function closely, as any changes could lead to abdominal discomfort.

2. Management: Encourage your father to communicate any changes in his pain to his healthcare team. They may suggest imaging studies or lab tests to assess his liver function and rule out any complications.


Treatment Decisions
1. Continuing Chemotherapy: The decision to continue chemotherapy should be made collaboratively with your father’s oncologist. It’s essential to weigh the potential benefits of treatment against the side effects and his quality of life. If his tumor markers are rising, it may indicate that the current treatment is not effective. However, some patients may still benefit from ongoing treatment, depending on their overall health and specific cancer characteristics.

2. Quality of Life Considerations: It’s crucial to consider your father’s wishes and quality of life. If he feels that the treatment is causing more distress than benefit, it may be worth discussing alternative options, including palliative care, which focuses on comfort and quality of life rather than curative treatment.

3. Supportive Care: Regardless of the treatment path chosen, supportive care is vital. This includes managing symptoms, providing nutritional support, and addressing emotional and psychological needs. Engaging a palliative care team can be beneficial, as they specialize in improving quality of life for patients with serious illnesses.

In conclusion, I recommend discussing these concerns with your father's healthcare team. They can provide tailored advice and support based on his specific situation. It’s essential to keep an open line of communication with them and advocate for your father's needs and preferences.

Wishing you and your father strength during this challenging time. Please feel free to reach out if you have more questions or need further assistance.

Best regards.

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