the Risks of Long-Term Use of Seroquel: Symptoms and Concerns

Will overeating Tinos cause these symptoms?

Hello, doctor.
My sister has been suffering from sleep disorders and has been taking Seroquel (quetiapine) for about three years.
She started with a small dosage, but now she takes dozens of pills a day.
She feels very uncomfortable without the medication.
She has previously sought treatment from doctors, but her condition did not improve, and eventually, she stopped wanting to see a doctor and continued taking Seroquel long-term.
Now she is experiencing memory decline, tends to lie, feels irritable, and has disorganized speech, which seems to show signs of possible delusions.
I am unsure if these symptoms are side effects of the medication.
I have informed her that she needs to see a doctor, but she refuses and gets upset when I mention her condition.
I would like to ask if the medication could be causing brain damage.
If she continues to take it without medical supervision, could there be severe consequences? Is there a risk of sudden death? Thank you for your response.

dir, 20~29 year old female. Ask Date: 2009/01/08

Dr. Su Zongwei reply Psychiatry

Regarding the long-term side effects of excessive use of steroids, it is currently known that there can be memory impairment, a tendency to lie, irritability, disorganized speech, and signs that may resemble delusional disorders.
These symptoms may not necessarily be due to the medication itself but could be related to underlying mental health conditions.
As for sudden death or brain injury, there are currently no reports indicating such outcomes; however, all research findings pertain to normal usage levels, such as 1-2 pills per day.
Taking a large quantity at once (such as dozens of pills in a single day) is not considered a side effect but rather an overdose.
Even with normal substances, like water, there are no side effects when consumed in moderation, but drinking an excessive amount of water at once can lead to water intoxication, which can have unpredictable consequences.
Ultimately, it is crucial to advise the individual to seek medical attention, as there is likely an underlying condition that necessitates such high doses of steroids.

Reply Date: 2009/01/08

More Info

Long-term use of medications like Seroquel (Quetiapine) and other psychotropic drugs can raise significant concerns, particularly regarding their safety and potential side effects. Seroquel is an atypical antipsychotic primarily used to treat schizophrenia, bipolar disorder, and major depressive disorder. While it is generally considered effective for these conditions, the long-term implications of its use warrant careful consideration.

Safety Profile of Seroquel
Seroquel is known for its relatively favorable side effect profile compared to older antipsychotics. However, no medication is without risks. Common side effects include sedation, dizziness, dry mouth, constipation, and potential metabolic changes such as weight gain and increased blood sugar levels. More serious risks involve extrapyramidal symptoms (movement disorders), tardive dyskinesia, and, in rare cases, neuroleptic malignant syndrome, which can be life-threatening.

In your sister's case, the prolonged use of Seroquel or any similar medication, especially in high doses, can lead to cognitive impairments, emotional dysregulation, and even psychotic symptoms, as you described. The symptoms of memory decline, irritability, and possible delusions may not solely be attributed to the medication but could also be exacerbated by the underlying condition being treated or by withdrawal from the medication if she attempts to stop it suddenly.

Concerns with Long-Term Use
1. Cognitive Decline: Long-term use of antipsychotics has been associated with cognitive decline in some patients. This can manifest as memory issues, difficulty concentrating, and changes in behavior, which could explain your sister's symptoms.

2. Dependence and Withdrawal: Chronic use of sedative medications can lead to physical dependence. If your sister has been taking Seroquel in increasing doses, she may experience withdrawal symptoms if she attempts to stop. This can include rebound insomnia, anxiety, and irritability.

3. Psychiatric Symptoms: The emergence of symptoms such as irritability, mood swings, and even delusions can indicate that the medication is not effectively managing her condition or that it is contributing to a worsening of her mental health. It's crucial to differentiate between medication side effects and the underlying psychiatric disorder.

4. Risk of Sudden Death: While the risk of sudden death associated with Seroquel is low, it is not zero. Factors such as pre-existing health conditions, interactions with other medications, and the overall health of the patient can influence this risk.

Recommendations
Given the complexity of your sister's situation, it is essential to encourage her to seek medical advice. Here are some steps you can take:
- Consult a Psychiatrist: A mental health professional can evaluate her current medication regimen and determine if adjustments are necessary. This may include switching medications, adjusting dosages, or incorporating therapy.

- Monitor Symptoms: Keep a detailed record of her symptoms, behaviors, and any changes in her mental state. This information can be invaluable for her healthcare provider.

- Educate and Support: Help her understand the importance of medication management and the potential risks of long-term use. Sometimes, patients may respond better to treatment when they feel supported and informed.

- Explore Alternative Treatments: If she is open to it, discuss the possibility of non-pharmacological treatments such as cognitive behavioral therapy (CBT), mindfulness practices, or lifestyle changes that can improve her overall mental health.

In conclusion, while Seroquel can be effective for managing certain psychiatric conditions, its long-term use requires careful monitoring and management to mitigate risks and ensure the best possible outcomes for patients. Encourage your sister to engage with healthcare professionals who can provide the necessary support and guidance.

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