Choosing the Right Vaccine for Your Toddler: Six-in-One vs. Four or Five-in-One - Pediatrics

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Six-in-one


Hello Dr.
Hsiao: My baby is now 1.5 years old and is due for the hexavalent vaccine! However, when I called the previous hospital (Hospital A) where we received vaccinations, they informed me that they are currently out of stock and can only offer the pentavalent or quadrivalent vaccines, with no indication of when they will be available.
I then inquired at another hospital (Hospital B), which just received 10 doses of the hexavalent vaccine, so I need to go there soon for the vaccination! I'm unsure what to do because I have never been to Hospital B, but my neighbors and friends have received vaccinations there.
The hexavalent vaccine we previously received was from the brand "Infanrix Hexa." Are all hexavalent vaccines from this brand? Should I choose to go to Hospital B for the hexavalent vaccine, or should I opt for the pentavalent or quadrivalent vaccines at Hospital A? Thank you, doctor!

Xuan Mami, 20~29 year old female. Ask Date: 2009/02/12

Dr. Xiao Kaiwen reply Pediatrics


Currently, the six-in-one vaccine available on the market is exclusively from the BabyCare brand (GlaxoSmithKline).
In principle, if the six-in-one vaccine is out of stock, the Department of Health recommends administering the five-in-one or four-in-one vaccine for the fourth dose (which does not affect the efficacy of the hepatitis B vaccine).
However, if the six-in-one vaccine is still available, it is preferable to administer the six-in-one vaccine, as long as the healthcare facility is approved by the health department for vaccine administration.

Reply Date: 2009/02/12

More Info


When it comes to choosing the right vaccine for your toddler, particularly between the six-in-one (hexavalent) vaccine and the four-in-one or five-in-one vaccines, there are several factors to consider. Each vaccine has its own benefits and potential drawbacks, and understanding these can help you make an informed decision.

The six-in-one vaccine typically combines protection against six diseases: diphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus influenzae type b (Hib), and hepatitis B. This combination allows for fewer injections, which can be less stressful for both the child and the parent. The convenience of fewer visits to the clinic is also a significant advantage, especially for busy families.

On the other hand, the four-in-one vaccine generally covers diphtheria, tetanus, pertussis, and polio, while the five-in-one vaccine adds Hib to the mix. While these vaccines do not include hepatitis B, they still provide substantial protection against several serious diseases. If your child has already received the hepatitis B vaccine separately, then opting for a four-in-one or five-in-one vaccine could be a reasonable choice.

In your case, since your child is one and a half years old and you have the option of receiving the six-in-one vaccine at the second clinic (乙), it may be beneficial to go ahead with that option, especially if your child has not yet received the hepatitis B vaccine or if the previous doses were insufficient. The six-in-one vaccine will ensure that your child is fully protected against all six diseases in one shot, which can be particularly advantageous for maintaining their vaccination schedule.

However, if you have concerns about the clinic (乙) where you have not previously received care, it is essential to consider the reputation and reliability of the healthcare provider. If neighbors and friends have had positive experiences there, it may alleviate some of your concerns. It is also worth noting that the brand of the vaccine can vary, and while the hexavalent vaccines are generally similar in composition, it is always good to confirm with the healthcare provider about the specific brand and its efficacy.

If you choose to go to the first clinic (甲) for the four-in-one or five-in-one vaccine, ensure that your child has received the hepatitis B vaccine previously. If they have, this option is also valid and will still provide significant protection against the diseases covered.

In summary, if the six-in-one vaccine is available and your child is eligible for it, that may be the best option for comprehensive protection. However, if you feel more comfortable with the first clinic and your child has received the necessary vaccinations, the four-in-one or five-in-one vaccines are also effective. Ultimately, the decision should be based on your child's vaccination history, the availability of vaccines, and your comfort level with the healthcare provider. Always consult with your pediatrician for personalized advice tailored to your child's health needs.

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Wishing you peace and safety with the six-in-one or more.

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Can My Baby Get the Five-in-One Vaccine at Four Months?

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