the Differences Between Four-in-One and Five-in-One Vaccines for Children - Pediatrics

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Four-in-one and five-in-one?


Hello, Dr.
Pei! I have three questions for you:
1.
I noticed that the contraindication for the oral polio vaccine is "those currently taking corticosteroids." Since I am breastfeeding and occasionally experience headaches, my doctor prescribes Inderal (propranolol) for me, as other pain relievers do not work, and 10 mg is effective for pain relief.
I wait 24 hours after taking it before breastfeeding, during which time I express and discard my milk.
I am concerned about whether this will affect my child, as he is due for his second dose of the oral polio vaccine in one month (he received the first dose two months ago, and I have not taken Inderal since then).
Should I switch to the pentavalent vaccine instead?
2.
Additionally, is it acceptable to administer the first dose of the quadrivalent vaccine along with the oral polio vaccine, and then switch to the pentavalent vaccine for the second dose?
3.
Can the quadrivalent and pentavalent vaccines be administered simultaneously with the pneumococcal conjugate vaccine?

cynthia, 30~39 year old female. Ask Date: 2006/11/14

Dr. Pei Rensheng reply Pediatrics


Hello:
1.
Taking Inderal will not affect the oral polio vaccine; you can still receive the vaccine on schedule.

2.
The first dose is the , and the second dose can be switched to the five-in-one injectable vaccine, which is acceptable.

3.
Yes, the four-in-one or five-in-one vaccines can be administered alongside the pneumococcal vaccine.
However, it is important to note that the pneumococcal vaccine should not be given together with the whole-cell three-in-one vaccine.

Wishing you health and happiness!
Sincerely,
Pei Ren-Sheng

Reply Date: 2006/11/14

More Info


When considering the differences between four-in-one and five-in-one vaccines for children, it's essential to understand the components and the implications of each vaccine type. The four-in-one vaccine typically includes protection against diphtheria, tetanus, pertussis (whooping cough), and polio. In contrast, the five-in-one vaccine adds protection against Haemophilus influenzae type b (Hib), which can cause severe infections, particularly in young children.

1. Concerns Regarding Inderal and Oral Polio Vaccine: You mentioned taking Inderal (propranolol) for headaches while breastfeeding. The concern about the oral polio vaccine (OPV) being contraindicated for those on corticosteroids is valid, but Inderal is not a corticosteroid and does not have the same implications. Therefore, your use of Inderal should not affect your child's ability to receive the oral polio vaccine. It's good practice to consult with your pediatrician regarding any medications you are taking while breastfeeding, but based on current guidelines, your child should be able to receive the second dose of the oral polio vaccine without concern. If you are considering switching to the five-in-one vaccine, it is generally acceptable to do so, as it provides broader protection.

2. Switching from Four-in-One to Five-in-One: It is perfectly acceptable to administer the first dose of a four-in-one vaccine followed by a five-in-one vaccine for the second dose. The five-in-one vaccine includes the same components as the four-in-one, plus Hib, which is beneficial for your child's health. This approach is often recommended to ensure comprehensive immunization coverage, especially since Hib can lead to serious infections such as meningitis and pneumonia.

3. Co-administration with Pneumococcal Vaccine: Both the four-in-one and five-in-one vaccines can be administered alongside the pneumococcal vaccine. This is important because pneumococcal disease can cause severe infections in children, and co-administration can help streamline the vaccination process without compromising the immune response. However, it is crucial to avoid administering live vaccines (like the oral polio vaccine) simultaneously with other live vaccines unless specifically indicated. In your case, since the five-in-one vaccine contains an inactivated form of the polio vaccine, it can be given together with the pneumococcal vaccine without any issues.

In summary, both the four-in-one and five-in-one vaccines are crucial for protecting children against serious diseases. The five-in-one vaccine offers additional protection against Hib, making it a valuable option. Your use of Inderal does not contraindicate the oral polio vaccine, and switching from a four-in-one to a five-in-one vaccine is acceptable. Additionally, both vaccines can be administered alongside the pneumococcal vaccine, ensuring your child receives comprehensive immunization. Always consult with your healthcare provider for personalized advice and to address any specific concerns regarding your child's vaccination schedule.

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