Asymptomatic Syphilis: What Positive Test Results Mean - Urology

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Regarding asymptomatic syphilis with positive syphilis test results?


I was found to have a positive reaction for syphilis during a blood donation, so I went to a major hospital for two follow-up tests related to syphilis two to three days later.
I initially thought it might be a false positive, but the second confirmatory test—the treponemal antigen test—also came back positive.
I would like to ask the doctor: I do not have any external signs of syphilis (I initially thought it was external to the anus, but after an examination by a colorectal surgeon, the doctor said it was external hemorrhoids).
Additionally, I had just finished taking medication for a toothache a few days before the blood donation, and I asked the doctor if that would affect the test results, which they said it would not.
This has left me quite confused about what is going on.

Furthermore, I have read that syphilis is treatable, but can the TPHA test remain positive for life? Is it also possible for it to turn negative? (I understand that as long as the VDRL test is negative, that is sufficient.) Additionally, the information I found indicates that with consistent treatment, one can be completely cured in about one month, is that correct? If a family member washes my clothes, is there a risk of transmission?

Xiao Shu, 20~29 year old female. Ask Date: 2009/02/13

Dr. Yan Dawei reply Urology


Syphilis infection is treatable.
As for the blood test results, you can consult a urologist or an infectious disease specialist for further examination and have the physician explain the findings.

Reply Date: 2009/02/13

More Info


Understanding asymptomatic syphilis can be quite complex, especially when faced with positive test results. Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. It can present in various stages, and many individuals may remain asymptomatic, meaning they show no visible signs or symptoms of the disease.
In your case, the initial positive result during blood donation followed by a confirmatory positive test for Treponema pallidum (TPHA) indicates that you have been exposed to the syphilis bacterium at some point. It’s important to note that a positive TPHA test does not necessarily mean you have active syphilis; it simply indicates that you have been infected at some time, which could be in the past or present.
The fact that you are asymptomatic is not uncommon. Many individuals with syphilis do not exhibit symptoms, especially in the early stages. The absence of symptoms does not mean that the infection is not present or that it is not serious. It is crucial to follow up with your healthcare provider for further evaluation and treatment.

Regarding your question about the possibility of the TPHA test remaining positive for life, yes, it is possible. The TPHA test can remain positive even after successful treatment of syphilis. This is because the test detects antibodies produced in response to the infection, and these antibodies can persist long after the infection has been cleared. However, the VDRL (Venereal Disease Research Laboratory) test, which is a non-treponemal test, is used to monitor treatment response. A negative VDRL test after treatment indicates that the infection has been effectively treated.

As for your concern about transmission, syphilis is primarily transmitted through sexual contact. It is less likely to be transmitted through casual contact, such as sharing clothing or bedding. However, it is always best to practice safe sex and inform any sexual partners if you have been diagnosed with syphilis, even if you are currently asymptomatic.

In terms of treatment, syphilis is highly treatable, typically with antibiotics such as penicillin. If you adhere to the treatment regimen prescribed by your healthcare provider, you can expect to be cured of the infection. Follow-up testing is usually recommended to ensure that the infection has been cleared and to monitor for any potential reinfection.

In summary, while a positive TPHA test indicates past exposure to syphilis, being asymptomatic does not diminish the importance of seeking treatment. It is essential to work closely with your healthcare provider to ensure proper management of your condition. Regular follow-ups and testing will help ensure that you remain healthy and free from syphilis in the future.

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