Harnalidge: Nighttime Urination and Side Effects Explained - Urology

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Harnalidge, a medication commonly used to treat symptoms of benign prostatic hyperplasia, may cause nocturia (frequent urination at night) in some individuals, especially if taken before bedtime.
It can also lead to urinary retention in rare cases.
The warning on the medication packaging about not standing up quickly is to prevent dizziness or orthostatic hypotension, which can be side effects of the medication.

The discomfort in your lower abdomen due to prostate inflammation is a common symptom and can be considered a normal reaction to the condition.

Regarding your concerns about infection, it is important to note that urinary tract infections can occur without any obvious risk factors or inappropriate behaviors.
Chronic infections can be particularly distressing, and it is advisable to discuss your fears and symptoms with your healthcare provider for further evaluation and management.
Thank you.

Chen R, 40~49 year old female. Ask Date: 2009/04/16

Dr. Xu Weikai reply Urology


Hello, Harnalidge belongs to a new generation of medications with minimal side effects and can be used at any time.
Physicians often recommend taking it before bedtime because the previous generation of medications had side effects such as lowering blood pressure.
Therefore, it has become a common practice to advise taking these medications at night and to avoid standing up too quickly to prevent dizziness.
Harnalidge generally does not affect blood pressure and does not have such side effects.
Discomfort in the pelvic area due to prostatitis is quite common.
Prostatitis is not classified as a sexually transmitted disease and is not significantly related to sexual activity.
More relevant factors include urinary retention and insufficient fluid intake.
Chronic inflammation occurs when inflammation persists without resolution, leading to complications such as fibrosis, which can be challenging to treat and requires patience.
If there are any unclear points, feel free to ask again for further discussion and research.
Sincerely, Dr.
Hsu Wei-Kai, Director of Urology, Taitung Hospital, Department of Health, Executive Yuan.

Reply Date: 2009/04/16

More Info


Harnalidge, a medication commonly prescribed for the treatment of benign prostatic hyperplasia (BPH), can indeed have effects on urination patterns, particularly when taken at night. This medication works by relaxing the muscles in the prostate and bladder neck, which can help improve urine flow and reduce symptoms associated with BPH. However, it is important to understand how it may affect nighttime urination and other potential side effects.

When taken before bedtime, Harnalidge can lead to increased urination during the night, a condition known as nocturia. This is because the medication may cause the bladder to become more sensitive or may alter the normal patterns of urine production and storage. While some patients may experience relief from urinary symptoms during the day, they might find themselves waking up multiple times at night to urinate, which can disrupt sleep and lead to fatigue.

On the other hand, Harnalidge can also cause side effects that may lead to difficulty in urination. Some patients may experience a paradoxical reaction where the medication causes urinary retention instead of relief. This can occur due to the relaxation of the bladder neck muscles, which can sometimes lead to an inability to fully empty the bladder. If you experience any difficulty urinating or a feeling of incomplete bladder emptying, it is crucial to consult your healthcare provider immediately.

The warning on the medication label about not standing up quickly is related to the potential for orthostatic hypotension, a condition where blood pressure drops significantly when standing up. This can lead to dizziness or fainting, especially in the elderly or those who are dehydrated. It is advisable to rise slowly from a sitting or lying position to minimize this risk.

Regarding your concerns about chronic infections and discomfort in the lower abdomen, it is not uncommon for men with prostate issues to experience discomfort due to inflammation or irritation of the surrounding tissues. Chronic infections can occur for various reasons, including bacterial infections, inflammation, or even non-infectious causes related to the prostate itself. If you have not engaged in high-risk behaviors, it is still possible to develop infections due to other factors, such as anatomical predispositions or underlying health conditions.

Chronic prostatitis or pelvic pain syndrome can also manifest as persistent discomfort and may require a comprehensive evaluation by a urologist. They may recommend tests to determine the underlying cause of your symptoms and suggest appropriate treatments, which may include antibiotics, anti-inflammatory medications, or other therapies.

In summary, while Harnalidge can be effective for managing symptoms of BPH, it is essential to monitor its effects on your urination patterns and overall well-being. If you experience increased nighttime urination, difficulty urinating, or persistent discomfort, it is important to communicate these issues with your healthcare provider. They can help assess your situation, adjust your treatment plan if necessary, and provide guidance on managing your symptoms effectively. Additionally, addressing any underlying infections or chronic conditions is crucial for your overall health and comfort.

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