Comparing Birth Control Pills for Acne Treatment: Yaz vs. Alesse - Pharmacology

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Oral contraceptives for the treatment of acne?


Hello, I have polycystic ovary syndrome, and I experience acne and premenstrual syndrome.
My gynecologist prescribed "Yaz" birth control pills for treatment, but they are expensive.
I asked the pharmacist at a nearby pharmacy, and they do not sell "Yaz," but the pharmacist recommended "Alesse" as a substitute, which is cheaper.
I have been taking it for 8 days, but I feel a bit uneasy, and now I have some breast tenderness and slight bleeding.
I would like to ask: Can these two medications be substituted for each other? Is there a significant difference between them? Which one is more effective for treating acne? Which has fewer side effects? This is my first time taking birth control pills, and my main goal is to treat acne, not for contraception.
If I switch back to "Yaz," is that possible? How should I transition between the medications?

Jessie, 20~29 year old female. Ask Date: 2009/07/15

Dr. Hou Fangmin reply Pharmacology


Hello: The ingredients in YAZ are ethinyl estradiol (an estrogen) and drospirenone (DRSP).
Alesse contains cyproterone and ethinyl estradiol at a dosage of 0.035 mg.
These two medications have different components.
Common side effects of oral contraceptives include edema, breast pain, acne, and breast tenderness.
If estrogen levels are too high, it can also cause dizziness and headaches.
The latest formulation of DRSP has fewer side effects.
Both are contraceptives, but some may use them to treat acne.
If you wish to switch back to YAZ, you can do so as long as you follow the instructions on the medication label or those provided by your physician or pharmacist.
Wishing you safety and happiness.

Reply Date: 2009/07/15

More Info


When it comes to managing acne, particularly in patients with polycystic ovary syndrome (PCOS), birth control pills can be an effective treatment option. In your case, you have been prescribed Yaz (drospirenone and ethinyl estradiol), which is known for its efficacy in treating acne due to its anti-androgenic properties. On the other hand, Alesse (levonorgestrel and ethinyl estradiol) is another oral contraceptive that is often used for birth control and can also help with acne, but it may not be as effective as Yaz for this specific purpose.


Comparison of Yaz and Alesse
1. Composition:
- Yaz contains drospirenone, which is a progestin that has anti-androgenic effects. This means it can help reduce the levels of male hormones that contribute to acne and other symptoms of PCOS.

- Alesse contains levonorgestrel, which is a progestin that does not have the same anti-androgenic properties as drospirenone. This could make Yaz a more suitable option for treating acne in women with PCOS.

2. Efficacy for Acne:
- Studies have shown that Yaz is particularly effective in treating acne due to its ability to lower androgen levels, which can lead to a decrease in sebum production and, consequently, acne lesions.

- Alesse may help with acne, but it is generally considered less effective than Yaz for this specific condition.

3. Side Effects:
- Both medications can have side effects, including breast tenderness, mood changes, and breakthrough bleeding. However, the side effects can vary from person to person.

- Some patients report that Yaz has a more favorable side effect profile due to its unique formulation, but individual experiences can differ.


Switching Between Medications
If you have been taking Alesse for eight days and are experiencing breast tenderness and light bleeding, it is essential to consult your healthcare provider before making any changes. These symptoms can be common when starting a new birth control pill, but they should be monitored.

If you decide to switch back to Yaz, it's generally recommended to wait until the end of your current pack of Alesse before starting Yaz. This helps to maintain consistent hormone levels and reduces the risk of breakthrough bleeding. You can start Yaz the day after finishing your last Alesse pill. However, it’s crucial to discuss this with your healthcare provider, as they can provide personalized advice based on your medical history and current health status.


Conclusion
In summary, Yaz is likely to be more effective for treating acne associated with PCOS compared to Alesse due to its anti-androgenic properties. If you are considering switching back to Yaz, consult with your healthcare provider to ensure that it is the right decision for you and to discuss the best way to make the transition. They can also help monitor any side effects you may experience and adjust your treatment plan as necessary. Remember, managing PCOS and acne often requires a comprehensive approach, including lifestyle modifications and possibly other treatments, so keep an open line of communication with your healthcare team.

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