Choosing the Right Care Solution for Silicone Hydrogel Contact Lenses - Ophthalmology

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Choosing Care Solutions for Silicone Hydrogel Contact Lenses


Hello, Doctor: I would like to ask if contact lenses made of silicone hydrogel require the use of special care solutions.
During my research, I found that care solutions containing PHMB as a primary ingredient seem to adhere to the lenses and could potentially harm the eyes.
However, much of this information appears to be overly concentrated from a specific manufacturer.
Therefore, I would like to inquire whether the following statement is true: Are there sufficient clinical instances to confirm that care solutions primarily containing PHMB can easily damage the cornea when cleaning silicone hydrogel contact lenses? (Excerpt from this website: http://hospital.kingnet.com.tw/essay/essay.html?pid=18737&category=%C2%E5%C3%C4%AFe%AFf&type=) *Does it harm corneal epithelial cells? 1.
Macromolecular disinfectants - do not remain in the eye, causing damage to corneal epithelial cells.
2.
Small molecular disinfectants like PHMB: can easily penetrate the pores of silicone hydrogel lenses, remaining in the eye and harming corneal epithelial cells.
I need to use contact lenses soon but am skeptical about biased information.
I would appreciate your clarification on this matter.
Thank you!

Ellmer, 20~29 year old female. Ask Date: 2009/12/25

Dr. Wang Zhishun reply Ophthalmology


Hello: PHMB (Polyhexamethylene Biguanide) has been used in the treatment of ocular infections; its potential ocular toxicity is related to its concentration.
Currently, the concentrations found in commercially available contact lens solutions do not exceed those used in the treatment of ocular infections, so they should not cause harm.
Regarding the care solutions for silicone hydrogel contact lenses, a large-scale international study has been ongoing since January 2009.
Until the results are available, it is recommended to use the manufacturer's care solutions.
I hope this information is helpful to you.
Best wishes!

Reply Date: 2009/12/25

More Info


When it comes to caring for silicone hydrogel contact lenses, selecting the right care solution is crucial for maintaining eye health and ensuring the comfort of the lenses. Silicone hydrogel lenses are designed to allow more oxygen to reach the cornea compared to traditional hydrogel lenses, which is beneficial for eye health. However, this increased oxygen permeability also means that the choice of cleaning and disinfecting solutions is particularly important.

One of the concerns raised in your question is regarding the use of solutions containing Polyhexamethylene Biguanide (PHMB). PHMB is a common antimicrobial agent used in some contact lens solutions. While it is effective in killing bacteria, there are concerns about its potential to leave residues on silicone hydrogel lenses. This is particularly relevant because silicone hydrogel materials have a unique structure that can allow smaller molecules, like those of PHMB, to penetrate and remain within the lens material.
The fear that PHMB can cause damage to the corneal epithelial cells stems from studies that suggest that prolonged exposure to certain concentrations of PHMB may lead to cytotoxic effects. However, it is essential to note that the concentrations used in commercially available contact lens solutions are typically much lower than those used in therapeutic settings for treating infections. Most reputable manufacturers conduct extensive testing to ensure that their products are safe for use with silicone hydrogel lenses.
Clinical studies have shown that while there may be some risk associated with the use of PHMB-containing solutions, the actual incidence of corneal damage in users of silicone hydrogel lenses is relatively low when these products are used as directed. The key is to follow the manufacturer's instructions and recommendations for lens care. If you have specific concerns about a particular product, it is advisable to consult with an eye care professional who can provide guidance based on your individual circumstances.

In general, when selecting a care solution for silicone hydrogel lenses, consider the following tips:
1. Manufacturer Recommendations: Always use cleaning and disinfecting solutions recommended by the lens manufacturer. These products are specifically formulated to work with the lens material and maintain its integrity.

2. Avoid Harsh Chemicals: Stay away from solutions that contain harsh preservatives or chemicals that may irritate the eyes or damage the lenses. Look for preservative-free options if you have sensitive eyes.

3. Compatibility: Ensure that the solution is compatible with silicone hydrogel lenses. Many solutions are labeled as suitable for all types of contact lenses, but it's always best to double-check.

4. Consult Your Eye Care Professional: If you have any doubts or specific concerns about the products you are using, consult with your eye care provider. They can recommend the best options based on your eye health and lifestyle.

5. Regular Check-ups: Regular eye examinations are crucial for monitoring the health of your eyes and ensuring that your contact lens regimen is appropriate.

In conclusion, while there are valid concerns regarding the use of PHMB in contact lens solutions, the risk of significant harm when using reputable products as directed is generally low. It is always best to consult with an eye care professional for personalized advice and to ensure the health and safety of your eyes while using contact lenses.

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