Rheumatoid Arthritis and Depression
Hello Dr.
Su, I am consulting for a friend’s child, a male student in the second year of a private high school.
He is 163 cm tall and weighs 48 kg.
He wakes up at 6 AM and finishes evening study at 9:30 PM.
He works hard to prepare for exams but can only maintain an average ranking.
He is under significant academic pressure and is currently on leave from school due to symptoms that began with chest pain, generalized muscle soreness, tremors, weakness, and a feeling of tightness in the chest, along with nausea.
A chest X-ray was normal, and blood tests showed ASO levels >200, leading to a suspected diagnosis of rheumatic fever, for which he received intravenous treatment with Chuanxiong.
After a week of medication without improvement, he switched hospitals and was reassessed by a psychiatrist, who diagnosed him with depression and prescribed Deanxit.
After five days on Deanxit, his sleep improved, and the nausea completely subsided, but he still experienced chest tightness and shortness of breath.
He changed hospitals again, where the doctor reaffirmed the diagnosis of depression but advised against Deanxit due to its significant side effects.
Instead, he was prescribed Efexor and Seroquel 200 mg (AstraZeneca).
On the first day of taking the new medication, he felt fatigued but had normal sleep.
By the third day, he experienced nausea and vomiting during meals, a lack of appetite, severe insomnia, significant eyelid twitching, and oral tremors.
He felt weak, anxious, and disoriented, with his heart rate increasing from 77 to 80 bpm.
He decided to stop the medication.
What medication would be appropriate for him? There are differing opinions from the two doctors regarding the treatment.
It seems that he had a milder reaction to the side effects of Deanxit, but the other doctor was adamant about its significant side effects.
How can we determine if the medication is appropriate?
An Cheng, 10~19 year old female. Ask Date: 2010/06/06
Dr. Su Zongwei reply Psychiatry
The extent of side effects varies depending on the individual patient and their suitability for the medication, and it cannot be generalized.
If a patient experiences adverse reactions to a medication, they should return to the clinic to discuss with their physician about adjusting the medication to minimize side effects.
Rheumatoid arthritis is an autoimmune disease that has a significant impact on mood; therefore, the emotional and pharmacological responses of these patients may differ from those of the general population, requiring more careful management.
Reply Date: 2010/06/06
More Info
Understanding the link between rheumatism and depression in teenagers is a complex issue that requires a nuanced approach. Rheumatism, often characterized by inflammation and pain in the joints, can significantly impact a young person's quality of life. When combined with the pressures of adolescence—such as academic stress, social dynamics, and family issues—this can lead to or exacerbate symptoms of depression.
In the case you presented, the young male student is experiencing a range of physical and emotional symptoms. His initial presentation of chest pain, muscle soreness, and feelings of weakness could be indicative of a rheumatic condition, particularly given the elevated ASO (anti-streptolysin O) titer, which suggests a possible post-streptococcal infection leading to rheumatic fever or other rheumatic diseases. The physical discomfort and chronic pain associated with rheumatism can lead to feelings of helplessness and frustration, which are common precursors to depression.
The transition from physical symptoms to a diagnosis of depression is not uncommon. Chronic pain conditions can lead to significant emotional distress. The constant battle with pain can drain a person's energy and motivation, leading to a cycle of inactivity, social withdrawal, and ultimately, depression. The young man’s academic struggles and the pressure to perform well in school can further compound his feelings of inadequacy and despair.
The medications prescribed—Deanxit, Efexor, and Seroquel—are all used to treat various aspects of depression and anxiety. However, the side effects experienced by the patient, such as nausea, loss of appetite, insomnia, and involuntary movements, indicate that finding the right medication can be a challenging process. It’s important to remember that each individual reacts differently to medications, and what works for one person may not work for another.
In this case, it seems that the patient had a better tolerance for Deanxit, despite the concerns raised by one of the doctors regarding its side effects. The key here is to monitor the patient's response to the medication closely. If Deanxit alleviates some symptoms without causing severe side effects, it may be worth discussing with the healthcare provider the possibility of continuing or adjusting the dosage rather than switching to a new medication that may have more severe side effects.
It is also crucial to consider a multidisciplinary approach to treatment. Alongside medication, psychotherapy can be beneficial. Cognitive-behavioral therapy (CBT) is particularly effective for treating depression and anxiety, helping individuals develop coping strategies and address negative thought patterns. Additionally, involving a rheumatologist may provide insights into managing the physical symptoms of rheumatism, which could, in turn, alleviate some of the emotional distress.
In conclusion, the relationship between rheumatism and depression in teenagers is multifaceted and requires careful management. It is essential to work closely with healthcare providers to find the most effective treatment plan, which may include medication, therapy, and lifestyle changes. Regular follow-ups and open communication about symptoms and side effects will be key in navigating this challenging situation. Encouraging the young man to express his feelings and concerns about his treatment can also empower him in his recovery journey.
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