Post-Surgery Complications: Managing Fever and Albumin Levels - Surgery

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Post-operative deterioration after gastric surgery with recurrent fever? -3


Hello, doctor.
It has been a month since I last asked a question, and I appreciate your response.
My mother has been in the ICU for 2.5 months and has been intubated for the same duration.
She has been experiencing recurrent fevers, which have been controlled between 37 and 38 degrees Celsius.
For the past week, she has been taking L-glutamine, and I feel that she has regained some strength.
However, the ICU physician mentioned that her albumin level has slightly decreased (2.2).
Since the National Health Insurance has already covered three bottles, which were used right after her surgery, they suggested that we pay out of pocket for albumin injections.
I would like to ask if whey protein is the same as albumin, or if we can buy whey protein as a substitute for albumin? Are there any other alternatives? (The hospital requires two bottles of albumin injections per day, recommending treatment for 3-7 days, with each bottle costing around 1500 NTD.) Thank you for your patient response.

takashi, 30~39 year old female. Ask Date: 2010/06/29

Dr. Ke Fangxu reply Surgery


Hello: In response to your question, whey protein is a complete protein that contains all essential amino acids required by the body and is easily absorbed.
However, it is generally taken orally and is not suitable for injection.
Albumin, on the other hand, can be administered via injection, bypassing the digestive process for more direct utilization by the body.
If the patient is able to eat, obtaining protein through dietary sources is preferable.
While albumin is not inherently problematic, it cannot be used indefinitely due to economic considerations and the potential for intestinal and liver degradation from prolonged fasting.
If the patient's basic condition is stable, I personally believe that oral intake is the better option.

Reply Date: 2010/06/29

More Info


Post-surgery complications can be quite challenging, especially when dealing with issues like fever and low albumin levels. Your mother’s prolonged stay in the ICU and the need for intubation indicate that she has undergone significant medical interventions, likely due to serious health concerns. The fact that she has been experiencing recurrent fevers, albeit controlled between 37-38 degrees Celsius, suggests that her body is still responding to some form of stress or infection, which is not uncommon in post-operative patients, particularly those who have had extensive surgeries or have underlying health conditions.

Fever in the post-operative setting can arise from various causes, including infections, inflammatory responses, or even reactions to medications. Continuous monitoring and appropriate management are crucial. The use of antipyretics (fever-reducing medications) may help in managing her fever, but it’s essential to identify and treat the underlying cause if an infection is suspected.

Regarding the albumin levels, a serum albumin level of 2.2 g/dL is considered low and may indicate a state of malnutrition, liver dysfunction, or ongoing inflammation. Albumin is a protein made by the liver, and it plays a vital role in maintaining oncotic pressure and transporting various substances in the blood. Low levels can lead to complications such as edema and impaired wound healing, which can further complicate recovery.

The recommendation from the ICU physician to consider albumin injections is based on the need to restore adequate protein levels in the body. While L-glutamine is an amino acid that can help with recovery and may support immune function, it is not a direct substitute for albumin. Whey protein, which you mentioned, is a high-quality protein source that can help increase overall protein intake, but it does not provide the same physiological functions as albumin.
Whey protein can be beneficial for general nutritional support and may help in muscle recovery and immune function, but it should not be seen as a replacement for albumin infusions, especially in a clinical setting where precise protein levels are critical. If your mother’s healthcare team has recommended albumin injections, it is likely because they believe that her current nutritional status and protein levels require more immediate and targeted intervention than what dietary supplements can provide.

In terms of alternatives, while dietary protein sources (like whey protein) can support overall nutrition, they may not be sufficient to correct low albumin levels in a short time frame. Other options might include high-protein enteral nutrition formulas if she is able to tolerate oral intake or tube feeding, depending on her condition and ability to swallow safely.

It’s crucial to have an open dialogue with her healthcare providers about the best approach to manage her low albumin levels and any potential alternatives to albumin injections. They can provide tailored recommendations based on her specific medical history, current condition, and nutritional needs.

In summary, managing post-surgery complications like fever and low albumin levels requires a comprehensive approach that includes monitoring, appropriate medical interventions, and nutritional support. While whey protein can be a helpful supplement, it should not replace the need for medical treatments like albumin injections when indicated. Always consult with her healthcare team before making any changes to her treatment plan.

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