Uterine Contraction Medications: Side Effects and Next Steps - Obstetrics and Gynecology

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Uterotonics


Hello, I would like to ask: 20 days ago, I went to a certain obstetrics and gynecology clinic and took RU486.
After that, the doctor prescribed a uterine contraction medication to be taken after breakfast and dinner for 7 days.
I returned for a follow-up after 7 days.
The doctor examined me and instructed me to take 2 additional pills because a urine test still indicated pregnancy.
Another 7-day supply of uterine contraction medication was prescribed, and I returned for another follow-up.
The result was the same as before; I took 2 pills again and was given a 10-day supply of uterine contraction medication.
Could these medications be causing my lower back pain? Should I continue taking these medications, or should I consider switching to another gynecologist? Please help me with this.
Thank you!

Pipi, 30~39 year old female. Ask Date: 2011/02/26

Dr. Yang Wangjun reply Obstetrics and Gynecology


Hello: Generally, after taking RU-486, a stronger uterine contraction agent (Prostaglandin E2) is taken two days later, and abortion typically occurs within 3-4 hours after ingestion.
Of course, depending on the gestational age, there may be cases of incomplete abortion or failure.
In such cases, a dilation and curettage (D&C) procedure can be performed to resolve the issue.
I recommend seeking a second opinion.
Thank you for your message!

Reply Date: 2011/02/26

More Info


When it comes to medications that induce uterine contractions, such as those prescribed after taking RU486 (mifepristone), it is essential to understand both the intended effects and potential side effects. RU486 is typically used in medical abortions, and the subsequent medications prescribed are often aimed at facilitating the process and ensuring that the uterus contracts effectively to expel its contents.


Side Effects of Uterine Contraction Medications
The medications you are taking, which are likely prostaglandin analogs (like misoprostol), can indeed cause a range of side effects. Common side effects include:
1. Abdominal Cramping: This is a direct result of the medication's action on the uterus, causing it to contract. While cramping is expected, it can sometimes be severe.

2. Back Pain: Many women report experiencing lower back pain as a side effect of these medications. This can be due to the same uterine contractions that cause abdominal cramping, as the body responds to the changes occurring in the uterus.

3. Nausea and Vomiting: Some individuals may experience gastrointestinal upset, which can accompany the use of these medications.

4. Diarrhea: Prostaglandins can stimulate the intestines, leading to diarrhea in some cases.

5. Headaches and Dizziness: Hormonal changes and the body's response to the medication can lead to headaches or feelings of dizziness.


Next Steps
Given your situation, where you have been prescribed multiple rounds of uterine contraction medications and are still testing positive for pregnancy, it is crucial to follow up with your healthcare provider. Here are some considerations:
1. Continue Monitoring: If your doctor has advised you to continue taking the medications, it is essential to follow their guidance. However, if you are experiencing significant discomfort or side effects, you should communicate this to your healthcare provider.

2. Seek Clarification: If you have concerns about the effectiveness of the treatment or the side effects you are experiencing, do not hesitate to ask your doctor for clarification. Understanding the purpose of each medication and what to expect can alleviate anxiety.

3. Consider a Second Opinion: If you feel uncertain about the treatment plan or if your symptoms persist without improvement, seeking a second opinion from another gynecologist can be beneficial. It is your right to ensure that you are receiving the best possible care.

4. Report Side Effects: Make sure to inform your healthcare provider about any side effects you are experiencing, especially if they are severe or worsening. This information can help them adjust your treatment plan accordingly.

5. Follow-Up Appointments: Keep all scheduled follow-up appointments. These are critical for monitoring your progress and ensuring that the treatment is effective.


Conclusion
In summary, while medications that induce uterine contractions can lead to side effects such as back pain and cramping, it is essential to maintain open communication with your healthcare provider. If you have concerns about the ongoing treatment or the side effects you are experiencing, do not hesitate to seek further evaluation or a second opinion. Your health and well-being are paramount, and you deserve to feel comfortable and informed about your treatment options.

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