Your HSV II Antibody Test Results: What Does a 0.6 Mean? - Urology

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I underwent a type II antibody test for HSV II Ab IgG (by EIA), and the result was 0.6, which is negative and below the reference value of <20 RU/ml.
However, there is a note stating <20 RU/ml: Negative for IgG antibody against Herpes Simplex Virus II.
Could you please explain why my report indicates that I do not have herpes, yet still shows a result of 0.6? What does the note mean?

7, 20~29 year old female. Ask Date: 2011/04/19

Dr. Xu Weikai reply Urology


The test results indicate that there is no disease present.

Reply Date: 2011/04/19

More Info


Understanding your HSV II antibody test results can be quite confusing, especially when the numbers don't seem to align with your expectations. In your case, the HSV II Ab IgG test result of 0.6 is considered negative, as it is below the reference value of <20 RU/ml. The report clearly states that a result of less than 20 RU/ml indicates a negative result for IgG antibodies against the Herpes Simplex Virus II (HSV-2).
So, what does a result of 0.6 mean? Essentially, it indicates that there is no significant presence of IgG antibodies against HSV-2 in your bloodstream. IgG antibodies typically develop after an initial infection and can remain in the body for a long time, indicating past exposure to the virus. A negative result suggests that you have not been infected with HSV-2 at any point in the past, or if you were, it was not enough to trigger a detectable immune response.

The presence of a value like 0.6, while still negative, can be attributed to a few factors. First, it is important to understand that laboratory tests often have a range of values that can be interpreted as negative, borderline, or positive. In your case, 0.6 is simply a low value that falls within the negative range. It does not indicate an active infection or a recent exposure to the virus.
Moreover, the test may detect very low levels of antibodies that are not clinically significant. This can happen due to various reasons, such as cross-reactivity with other proteins or simply the natural variability of the immune response. In some cases, individuals may produce a very small amount of antibodies that do not reach the threshold required for a positive result.

It's also worth noting that the timing of the test can influence the results. If you were recently exposed to HSV-2, it might take some time for your body to produce detectable levels of antibodies. Typically, IgG antibodies can take several weeks to months to develop after an infection. Therefore, if you suspect recent exposure, it may be advisable to retest after a few weeks to confirm your status.

In conclusion, your test result of 0.6 indicates that you are negative for HSV-2 antibodies, meaning you likely do not have an HSV-2 infection. The presence of a low value like 0.6 is not unusual and does not imply any health concerns. If you have ongoing symptoms or concerns about your sexual health, it is always best to consult with a healthcare provider for further evaluation and guidance. They can provide personalized advice and may recommend additional testing if necessary. Remember, understanding your test results is crucial, but they are just one part of your overall health picture.

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