Brain Degeneration: Treatment Options for Seniors - Geriatrics

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What are the issues related to brain degeneration?


My mother is 68 years old and has been suffering from severe insomnia since mid-year.
After undergoing a CT scan at a certain hospital, it was found that she has signs of brain degeneration, specifically mild cerebral atrophy.
The doctor prescribed KNOWFUL, to be taken twice daily (1200 mg each time), stating that it can improve cerebral blood circulation and prevent dementia.
Is this effect real? Additionally, my mother is taking TRENTAL once daily at another hospital due to kidney issues.
Do these two medications have the same effect? Can they be taken together or should they be taken separately? Furthermore, I am considering purchasing ginkgo biloba at the pharmacy for my mother.
Would this significantly improve her brain degeneration (mild atrophy)? I would appreciate your response.
Thank you!

A Min, 30~39 year old female. Ask Date: 2011/09/19

Dr. Shen Zhengnan reply Geriatrics


Hello, A-Min.
Knowful, Trental, and Ginkgo biloba all have effects on improving cerebral circulation, but there are still questions about their ability to prevent dementia.
Although Ginkgo can be purchased at pharmacies, it may interact with other medications, so it's best to consult your primary care physician before use.
For Alzheimer's disease, the most established treatments currently are acetylcholinesterase inhibitors and similar medications.
Shen Zhengnan.

Reply Date: 2011/09/19

More Info


Understanding brain degeneration, especially in seniors, is a multifaceted issue that requires careful consideration of various treatment options and lifestyle modifications. In your mother’s case, at the age of 68, the diagnosis of mild brain atrophy raises concerns about cognitive health and the potential for developing conditions such as dementia.
Firstly, regarding the medications prescribed, Knowful (which contains Ginkgo biloba extract) is often used with the intent to improve cerebral blood flow and potentially enhance cognitive function. Some studies suggest that Ginkgo biloba may have a positive effect on memory and cognitive performance, particularly in individuals with mild cognitive impairment. However, the evidence is mixed, and while some patients report subjective improvements, the scientific consensus on its efficacy in preventing dementia remains inconclusive.

On the other hand, Trental (Pentoxifylline) is primarily used to improve blood flow by decreasing blood viscosity. It is often prescribed for conditions like peripheral vascular disease but is not specifically indicated for cognitive decline. While both medications aim to improve blood circulation, they do so through different mechanisms and are not directly interchangeable.
As for the concurrent use of Knowful and Trental, it is generally advisable to consult with your healthcare provider before combining these medications. There is no well-documented interaction between these two drugs, but individual responses can vary, especially considering your mother’s kidney issues. The healthcare provider can assess her overall health status and kidney function to determine the safety and appropriateness of using both medications together.

Regarding the addition of Ginkgo biloba from a pharmacy, it is crucial to approach this with caution. While Ginkgo is available over the counter, it can interact with other medications and may not be suitable for everyone, particularly those with certain health conditions or those taking anticoagulants. Therefore, discussing this option with her physician is essential before introducing any new supplements.

In terms of managing mild brain atrophy and cognitive decline, a holistic approach is often recommended. This includes:
1. Cognitive Stimulation: Engaging in mentally stimulating activities such as puzzles, reading, or learning new skills can help maintain cognitive function.

2. Physical Activity: Regular exercise is beneficial not only for physical health but also for brain health. It improves blood flow to the brain and can enhance cognitive function.

3. Healthy Diet: A diet rich in antioxidants, omega-3 fatty acids, and vitamins can support brain health. Foods like fish, nuts, berries, and leafy greens are often recommended.

4. Social Engagement: Maintaining social connections and engaging in community activities can help reduce feelings of isolation and depression, which are often linked to cognitive decline.

5. Regular Check-ups: Continuous monitoring by healthcare professionals can help manage any emerging symptoms and adjust treatment plans as necessary.

In conclusion, while medications like Knowful and Trental may offer some benefits, they should be part of a broader strategy that includes lifestyle changes and regular medical oversight. Always consult with healthcare professionals before making any changes to your mother’s treatment plan, especially given her existing health conditions. This comprehensive approach can help manage her condition effectively and improve her quality of life.

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