Does Not Fasting Affect the Accuracy of Health Checkup Results? - Internal Medicine

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Does undergoing a health check-up without fasting affect the interpretation of test results? Thank you?


Hello Director Li, I would like to ask you some questions regarding the health check report.
Our company is organizing a health check tour, but the hospital has scheduled the health check from 3 to 5 PM and advised us that fasting is not necessary, and we can have a light meal.
I would like to inquire whether it is acceptable for the tests, specifically the AC B/S and Abd Sona, to be done without fasting.
The test items are as follows, and I would appreciate it if you could help us determine whether the accuracy and interpretation of the results for the following tests will be affected by not fasting:
- Urine occult blood (OB)
- Urine protein (PRO)
- Urine glucose (GLU)
- pH value
- Hemoglobin (HB)
- White blood cells (WBC)
- Serum glutamate-pyruvate transaminase (SGPT)
- Creatinine
- Total cholesterol (CHOL)
- Triglycerides (T-G)
- Fasting blood sugar (AC Sugar)
- Chest X-ray (Chest-PA, digital)
Body fat percentage
- Ketones (KET)
- Nitrite (NIT)
- Urine urobilinogen (URO)
- White blood cells (LEU)
- Urine specific gravity (S.G.)
- Urine bilirubin (BILI)
- Red blood cells (RBC)
- Hematocrit (HT)
- Mean corpuscular volume (MCV)
- Mean corpuscular hemoglobin (MCH)
- Mean corpuscular hemoglobin concentration (MCHC)
- Platelets (PLT)
- Red cell distribution width (RDW)
- Platelet distribution width (PDW)
- Mean platelet volume (MPV)
- Platelet volume percentage (PCT%)
- Lymphocyte percentage (LYM%)
- Monocyte percentage (MONO%)
- Neutrophil percentage (NEUT%)
- Eosinophil percentage (EOS%)
- Basophil percentage (BASO%)
- Absolute lymphocyte count (LYM#)
- Absolute monocyte count (MONO#)
- Absolute neutrophil count (NEUT#)
- Absolute eosinophil count (EOS#)
- Absolute basophil count (BASO#)
- Serum glutamate-oxaloacetate transaminase (SGOT)
- Alkaline phosphatase (ALK-P)
- Total protein (T-P)
- Albumin (ALB)
- Globulin (GLOB)
- Albumin/globulin ratio (A/G)
- Alcoholic liver disease (γ-GT)
- Total bilirubin (T-BILI)
- Direct bilirubin (D-BILI)
- Blood urea nitrogen (BUN)
- Uric acid (UA)
- Amylase
- Rheumatoid arthritis factor
- Hepatitis B test: surface antigen (HBsAg)
- Hepatitis B test: surface antibody (Anti-HBs)
- Alpha-fetoprotein (A.F.P)
- Carcinoembryonic antigen (C.E.A) (for males)
- Prostate-specific antigen (PSA) (for females)
- Cancer antigen 125 (CA-125) (for both genders)
- Abdominal ultrasound
Thank you, Director Li.
Wishing you all the best.

Miss Su, 30~39 year old female. Ask Date: 2012/05/24

Dr. Li Huixiong reply Internal Medicine


Hello: Some laboratory test results can indeed be influenced by diet.
Below, I will list the tests and examinations that are recommended to be fasting for at least eight hours due to dietary effects, for your reference: urine glucose (GLU), pH, total cholesterol (CHOL), triglycerides (T-G), fasting blood glucose (AC Sugar), albumin (ALB), blood urea nitrogen (BUN), uric acid (UA).
As for abdominal ultrasound (for both males and females), it is still preferable to perform the examination while fasting.

Reply Date: 2012/05/24

More Info


Fasting before a health checkup can significantly influence the accuracy of certain laboratory tests. When it comes to the specific tests you mentioned, some are indeed affected by food intake, while others are not.
In general, fasting is recommended for tests that measure blood glucose levels, lipid profiles (cholesterol and triglycerides), and certain liver enzymes. For instance, tests like fasting blood sugar (AC B/S), total cholesterol (CHOL), and triglycerides (T-G) are particularly sensitive to recent food intake. Consuming food can lead to elevated levels of glucose and triglycerides, which may result in misleading interpretations of your health status.
For the tests you listed, here are some insights:
1. Blood Glucose (AC B/S): This test measures your blood sugar levels after fasting. Eating before the test can lead to artificially high readings, which may misrepresent your glucose metabolism and risk for diabetes.

2. Lipid Panel (Total Cholesterol and Triglycerides): Similar to blood glucose, lipid levels can be significantly affected by recent meals. Non-fasting lipid panels are becoming more common, but fasting is still recommended for accurate results, especially if you have a history of dyslipidemia.

3. Liver Enzymes (SGPT, SGOT): While these tests can be performed without fasting, fasting may provide a clearer picture of liver function, especially if you have concerns about liver health.

4. Urinalysis (e.g., urine glucose, protein): These tests are generally not affected by fasting. However, hydration status can influence results, so it's important to maintain adequate fluid intake.

5. Abdominal Ultrasound (Abd Sona): Fasting is often recommended for abdominal ultrasounds to reduce the presence of gas in the intestines, which can obscure imaging.
6. Other Blood Tests: Many of the complete blood count (CBC) parameters and other biochemical markers (like creatinine, urea nitrogen, etc.) are less affected by fasting. However, it’s always best to follow specific instructions provided by your healthcare provider.

In summary, while some tests can be performed without fasting, others, particularly those assessing glucose and lipid levels, are best done after a period of fasting. If you have already consumed food, it’s advisable to inform your healthcare provider, as they may interpret the results differently or recommend retesting under fasting conditions.
For future health checkups, if fasting is required, it's typically recommended to fast for at least 8-12 hours prior to the tests. This ensures that the results are as accurate as possible, allowing for better assessment and management of your health. If you have any concerns or specific conditions that might affect your test results, discussing these with your healthcare provider is crucial for personalized advice.

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