How Soon Can You Test for Antibodies After German Measles Vaccination? - Obstetrics and Gynecology

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How long after receiving the German measles vaccine can one check for the presence of antibodies?


Hello, doctor: How long after receiving the German measles vaccine can I check for the presence of antibodies? If antibodies are not produced, should I receive a booster shot? Thank you!

Bu Bu, 20~29 year old female. Ask Date: 2012/07/28

Dr. Liu Yuhong reply Obstetrics and Gynecology


The German measles vaccine provides 95% protection.
Currently, the Centers for Disease Control and Prevention (CDC) does not recommend checking for antibody production after vaccination.
If antibodies are not produced, there is no recommendation for a booster shot.
If you are concerned about becoming pregnant immediately after receiving the German measles vaccine, the CDC advises avoiding pregnancy for 4 weeks post-vaccination.

#Reference:
CDC PINKBOOK Rubella Vaccine
- Composition: Live virus (RA 27/3 strain)
- Efficacy: 95% (Range, 90%-97%)
- Duration of Immunity: Lifelong
- Schedule: At least 1 dose
#Related Links:
Public Version: http://www.cdc.gov/vaccines/vpd-vac/rubella/default.htm
Professional Version: http://www.cdc.gov/vaccines/pubs/pinkbook/rubella.html#immunity

Reply Date: 2012/07/28

More Info


After receiving the German measles vaccine, also known as the rubella vaccine, it is generally recommended to wait at least four weeks before testing for antibodies. This timeframe allows your immune system sufficient time to respond to the vaccine and produce the antibodies that confer immunity. The rubella vaccine is highly effective, with an efficacy rate of approximately 95%, meaning that most individuals will develop immunity after vaccination.

In the United States, the Centers for Disease Control and Prevention (CDC) does not routinely recommend antibody testing after vaccination unless there are specific concerns, such as a history of immunosuppression or other medical conditions that may affect the immune response. Therefore, if you are healthy and have received the vaccine according to the recommended schedule, routine antibody testing is typically unnecessary.

If you do undergo antibody testing and the results indicate that you have not developed antibodies, the CDC guidelines suggest that revaccination is not usually required. This is because the vaccine is designed to provide lifelong immunity in the vast majority of individuals. However, if you have specific concerns or if you are planning to become pregnant, it may be prudent to consult with your healthcare provider for personalized advice.

For women of childbearing age, it is important to note that the rubella vaccine is a live attenuated vaccine, and it is recommended to avoid pregnancy for at least four weeks after vaccination. This precaution is in place to prevent any potential risks to a developing fetus, as rubella infection during pregnancy can lead to serious congenital defects.

In summary, after receiving the German measles vaccine, you should wait at least four weeks before testing for antibodies. Routine testing is not typically recommended unless there are specific health concerns. If antibody testing shows no response, revaccination is generally not necessary, but it is always best to discuss your individual situation with a healthcare provider, especially if you are considering pregnancy.

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