Low Red Blood Cell Count and Its Implications for Health - Internal Medicine

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Regarding issues with red blood cells?


Hello, doctor.
Since I was young, during every blood test for health check-ups, the doctors have always reminded me that my red blood cell volume is low and my hemoglobin levels are also low.
I still remember a doctor from Changhua Christian Hospital during my middle school years mentioned that I might have mild thalassemia.
Today, I just received the results from the health check arranged by my company.
I will post the parts with red text online and ask for your diagnosis regarding my values:
- RBC (Red Blood Cell Count): 631 (Normal range: 440-620 million/mm³)
- MCV (Mean Corpuscular Volume): 67 (Normal range: 80-100 fL)
- MCH (Mean Corpuscular Hemoglobin): 21.1 (Normal range: 26.4-34.4 pg)
Could you please tell me if low hemoglobin and low red blood cell volume will correspondingly affect the red blood cell count? I do not smoke or drink alcohol.
Based on the values above, how serious is the impact on my health? Thank you for your response.

James, 20~29 year old female. Ask Date: 2012/08/08

Dr. Cai Zonglin reply Internal Medicine


Low hemoglobin (Hb) levels may result in symptoms such as fatigue, dizziness, palpitations, and pallor.
Low hemoglobin does not necessarily correlate with low hematocrit, as it depends on the type of anemia.
Further evaluation may be required, including tests for serum iron levels and hemoglobin electrophoresis.
Referral to a hematology clinic for follow-up may also be necessary.

Reply Date: 2012/08/08

More Info


Understanding low red blood cell (RBC) counts and their implications for health is crucial, especially when you have been consistently informed about your low hemoglobin (Hb) levels and mean corpuscular volume (MCV) during health check-ups. Your recent test results indicate that your RBC count is slightly elevated at 631 (normal range: 440-620 million/mm³), while your MCV is significantly low at 67 (normal range: 80-100 fL) and your mean corpuscular hemoglobin (MCH) is also low at 21.1 (normal range: 26.4-34.4 pg).
Low hemoglobin and low MCV can suggest a type of anemia, which is a condition characterized by a deficiency in the number or quality of red blood cells. Anemia can lead to various symptoms, including fatigue, weakness, pale skin, shortness of breath, and dizziness. The severity of these symptoms often correlates with the degree of anemia.
In your case, the low MCV indicates that your red blood cells are smaller than normal, a condition known as microcytic anemia. This type of anemia is often associated with iron deficiency or thalassemia (a genetic form of anemia). Given that you mentioned a previous diagnosis of mild thalassemia, it is possible that your current blood results are related to this condition. Thalassemia can lead to a lower production of hemoglobin, resulting in smaller red blood cells and lower MCH values.

To answer your question about whether low hemoglobin and low MCV affect red blood cell quantity: they can be interrelated, but not always directly. For instance, in cases of iron deficiency anemia, low iron levels lead to decreased hemoglobin production, which in turn affects the size and number of red blood cells. However, in thalassemia, the body may produce a normal or even increased number of red blood cells, but they are often smaller and less effective at carrying oxygen.

Regarding the potential health implications of your results, while your RBC count is slightly elevated, the low MCV and MCH suggest that your red blood cells may not be functioning optimally. This can lead to inadequate oxygen delivery to tissues, which can affect your overall energy levels and physical performance. However, since you do not smoke or drink alcohol, and if you are otherwise healthy, the immediate risks may be lower, but it is essential to monitor your condition.

It is advisable to follow up with a healthcare provider, preferably a hematologist, who can conduct further tests to determine the underlying cause of your anemia. Tests may include serum ferritin to check iron stores, a complete iron panel, and possibly hemoglobin electrophoresis to assess for thalassemia or other hemoglobinopathies.
In the meantime, focusing on a balanced diet rich in iron (such as lean meats, beans, and leafy greens) and vitamin C (which enhances iron absorption) can be beneficial. If iron deficiency is confirmed, your doctor may recommend iron supplements.
In summary, while your current blood results indicate some abnormalities, the implications for your health can vary based on the underlying cause. Regular monitoring and consultation with a healthcare professional are essential to manage your condition effectively.

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