How Long Do Side Effects of Shipleymin Last in Infants?

How long do the side effects of Shiplimin last?

Dear Dr.
Hsiao,
My younger brother is currently 6 months and 25 days old and has developed roseola.
We took him to see a doctor yesterday, who prescribed a bottle of "Chlorpheniramine" for him, advising us to give it four times a day at a dose of 2cc each time.
However, after administering the medication, he experienced drowsiness as a side effect, requiring someone to hold or shake him to wake him up.
His appetite remains good, but we started giving him Chlorpheniramine yesterday (September 17) and stopped today at noon (September 18).
It has been over 9 hours since his last dose, but he is still experiencing drowsiness.
I would like to ask Dr.
Hsiao how long the side effects of Chlorpheniramine are expected to last.

Zhuang Tai Tai, 20~29 year old female. Ask Date: 2012/09/18

Dr. Xiao Kaiwen reply Pediatrics

Chlorpheniramine is an antihistamine, and a common side effect is drowsiness.
This medication is short-acting, and if there are no other interacting medications, the effects of the drug should be minimal after discontinuation for half a day to 24 hours.

Reply Date: 2012/09/18

More Info

The side effects of Shipleymin (also known as Hydroxyzine) in infants, particularly the sedative effect, can vary based on several factors including the infant's age, weight, metabolism, and overall health. Hydroxyzine is an antihistamine that is often used to treat allergies, anxiety, and nausea, and it is known for its sedative properties.
In general, the sedative effects of Hydroxyzine can last anywhere from a few hours to up to 24 hours after the last dose, depending on the individual response of the child. Since your infant has been on the medication for a short period, it is likely that the sedative effects will gradually diminish as the drug is cleared from the body. Typically, the half-life of Hydroxyzine in children is around 20 to 25 hours, meaning that it takes about this amount of time for half of the drug to be eliminated from the body. However, the noticeable sedative effects may not last this long, especially if the medication was stopped.

Given that your infant has been experiencing sedation for over 9 hours after the last dose, it is not uncommon for some residual drowsiness to persist. This can be particularly pronounced in younger infants, as their bodies metabolize medications differently than older children or adults. If the sedation continues beyond 24 hours or if you notice any concerning symptoms such as difficulty waking, irritability, or changes in breathing, it is crucial to consult your pediatrician immediately.

In terms of management, it is essential to ensure that your infant is in a safe environment where they can rest comfortably. Monitor their feeding and hydration, as well as any other symptoms that may arise. If the sedation is accompanied by other symptoms such as rash, difficulty breathing, or unusual behavior, seek medical attention promptly.

In summary, while the sedative effects of Shipleymin can last several hours, they typically should not persist beyond 24 hours. Each child may react differently to medications, so close observation is key. If you have any concerns or if the sedation seems excessive, do not hesitate to reach out to your healthcare provider for further guidance. Your child's safety and well-being are the top priority.

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