Concerns About Spironolactone Use and Breast Cancer Risk - Dermatology

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Breast cancer and contraceptive pills?


Hello Dr.
Chen, I have been experiencing acne for a long time.
The medication prescribed to me has "diuretic" written on the bag, and I am wondering if it refers to Spironolactone.
Recently, I read in a magazine that it should not be taken if there is a family history of breast cancer.
My mother passed away from breast cancer.
During the period of taking the medication, I have had dark discharge every day, requiring the use of panty liners, but I have been on it for 23 months.
Currently, I am only taking antibiotics.
I am very concerned about whether this will increase my risk of developing breast cancer.
Thank you.

nancy, 20~29 year old female. Ask Date: 2002/03/15

Dr. Chen Yiying reply Dermatology


The diuretic you mentioned for treating acne is likely spironolactone.
In fact, there is no evidence to support that the use of spironolactone increases the risk of breast cancer; however, it is suggested that patients with a family history of breast cancer should avoid its use.
Since you have discontinued the medication and the association between this drug and breast cancer has not been established, there is no need to worry excessively.
However, given your family history of breast cancer, it is important to pay closer attention to your body.
In addition to self-examinations, you should also regularly consult a breast surgeon for examinations and mammograms, as this is crucial.

Reply Date: 2002/03/15

More Info


When it comes to the use of spironolactone, especially in the context of treating acne and concerns about breast cancer risk, it is essential to understand both the medication's purpose and the implications of family history regarding breast cancer.

Spironolactone is a potassium-sparing diuretic that is often prescribed for various conditions, including hypertension and heart failure. However, it is also commonly used off-label to treat acne, particularly in women, due to its anti-androgenic properties. This means it can help reduce the effects of male hormones (androgens) that can contribute to acne development.

Your concern about the potential link between spironolactone and breast cancer, particularly given your family history, is valid. It is well-documented that having a family history of breast cancer can increase an individual's risk of developing the disease. However, the relationship between spironolactone and breast cancer is not straightforward. Current research does not provide conclusive evidence that spironolactone increases the risk of breast cancer. Most studies have not found a direct correlation between the use of spironolactone and an increased incidence of breast cancer.

That said, some medical professionals recommend caution when prescribing spironolactone to patients with a family history of breast cancer. This is primarily due to the theoretical concern that hormonal medications could potentially influence breast tissue. However, the actual risk remains unproven, and many healthcare providers continue to prescribe spironolactone for acne treatment, even in patients with a family history of breast cancer, while closely monitoring their health.

In your case, it is crucial to have open communication with your healthcare provider. If you have concerns about spironolactone and its potential risks, particularly given your family history, discussing these with your doctor can help you make an informed decision. They may suggest alternative treatments for acne that do not carry the same concerns or may recommend regular monitoring and screenings, such as mammograms, to ensure any changes in breast health are detected early.

Additionally, it is important to note that the black discharge you mentioned could be a side effect of spironolactone, as hormonal medications can sometimes cause changes in menstrual cycles and discharge. If this symptom is bothersome or concerning, it is advisable to discuss it with your doctor, who may consider adjusting your treatment plan.

In summary, while there is no definitive evidence linking spironolactone to an increased risk of breast cancer, your family history warrants a cautious approach. Regular check-ups and screenings, along with open dialogue with your healthcare provider, are essential steps in managing your health and addressing any concerns you may have about your treatment. Remember, your health and peace of mind are paramount, and it is always best to advocate for yourself in medical discussions.

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