Does Anesthesia During Gastroscopy Affect Pregnancy and Fetal Health? - Gastroenterology and Hepatology

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Does the anesthesia used during gastroscopy have an impact on fertility?


I discovered I was pregnant this month and had an upper gastrointestinal endoscopy a couple of days around the time of conception.
I'm concerned whether the anesthesia used during the procedure could affect the pregnancy and if the fetus might be unhealthy.
Thank you for your response.

mó, 30~39 year old female. Ask Date: 2013/02/21

Dr. Chen Qifeng reply Gastroenterology and Hepatology


Hello: Generally speaking, the medications used for preparing for an upper gastrointestinal endoscopy do not have an impact, unless it involves anesthetics used for sedation during the procedure, which may affect the fetus.
Best regards, Dr.
Chi-Feng Chen, Taoyuan General Hospital, Department of Health.

Reply Date: 2013/02/21

More Info


The concern regarding the effects of anesthesia used during a gastroscopy on pregnancy and fetal health is quite valid, especially for those who have recently discovered they are pregnant. To address your question, it is essential to consider the types of anesthesia used, the timing of the procedure in relation to conception, and the overall safety profile of these medications during pregnancy.

Gastroscopy, or esophagogastroduodenoscopy (EGD), is often performed under sedation or general anesthesia. Common sedatives used include medications like fentanyl and midazolam (Dormicum). These drugs are classified based on their potential risks during pregnancy. For instance, fentanyl is categorized as a Class C drug, which means that risk cannot be ruled out, while midazolam is classified as a Class D drug, indicating that there is positive evidence of human fetal risk but may be used in life-threatening situations if the benefits outweigh the risks.

If the gastroscopy was performed just around the time of conception, it is unlikely that the anesthesia would have a significant impact on the embryo. The critical period for fetal development is typically during the first trimester, particularly the first 12 weeks, when the organs are forming. Since you mentioned that the procedure occurred shortly after conception, the embryo would have been in the very early stages of development, where the effects of external factors, including medications, are often less pronounced.

However, it is crucial to note that while the immediate effects of anesthesia on the embryo may be minimal, there are still uncertainties regarding long-term outcomes. The potential for teratogenic effects (causing malformations) exists, particularly with Class D medications, but these risks are often context-dependent. For example, if the procedure was necessary for a medical reason, the benefits of performing it may outweigh the potential risks associated with the anesthesia.

In your case, since you are now aware of your pregnancy, it is advisable to consult with your obstetrician or a maternal-fetal medicine specialist. They can provide personalized advice based on your medical history and the specifics of your situation. Regular prenatal care is essential to monitor the health of both you and your baby, especially after any medical procedures during early pregnancy.

In summary, while there are concerns regarding the use of anesthesia during gastroscopy and its potential effects on pregnancy, the immediate risks may be low if the procedure was performed early in the pregnancy. Continuous monitoring and open communication with your healthcare provider will be key in ensuring a healthy pregnancy moving forward. Always prioritize discussing any concerns with your doctor, as they can offer the most accurate and tailored advice for your situation.

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