Abnormal Liver and Urine Test Results: What You Need to Know - Gastroenterology and Hepatology

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Request for advice on health check-up results?


Two weeks ago, I underwent a health check-up, and the results showed some issues.
I would like the doctor to take a look at the main problems related to liver function and urinalysis.
In the liver function tests, there are two abnormal values: immunoglobulin at 1.9 (normal range 2.0–3.9) and the albumin/globulin ratio at 2.5 (normal range 1.0–1.8).
Here are some of the results:
- Albumin: 4.7 (normal range 3.8–5.3)
- GOT (AST): 22 (normal range 10–40)
- GPT (ALT): 18 (normal range 6–45)
- r-GT: 13 (normal range 7–50)
- ALK-P: 88 (normal range 38–126)
- Total protein: 6.6 (normal range 6.1–7.9)
- Total Bilirubin: 0.9 (normal range 0.4–1.3)
- Direct Bilirubin: 0.1 (normal range 0–0.4)
Given these results, should I be concerned about my liver? Additionally, in the urinalysis, there are three abnormal values highlighted in red: specific gravity (sp.gr) at >= 1.030 (normal range 1.002–1.025), urine protein at +/- (normal range -), and urine bilirubin at 1+ (no normal range).
All other results are normal.

I would like to add that I did weight training the day before my health check-up, so I am unsure if this might have affected the results, especially since the issues seem to be related to protein levels.
I would appreciate the doctor's insights.
Thank you!

kalls, 20~29 year old female. Ask Date: 2013/04/04

Dr. Chen Qifeng reply Gastroenterology and Hepatology


Hello: According to the report, liver function is generally normal.
The data on globulin and albumin does not indicate any liver function abnormalities.
As for the structure, a liver ultrasound examination is necessary.
Best wishes, Dr.
Chi-Feng Chen, Taoyuan General Hospital, Department of Health.

Reply Date: 2013/04/04

More Info


Understanding abnormal liver and urine test results can be quite concerning, especially when they indicate potential health issues. Based on the information you provided, let's break down the findings from your liver function tests and urine analysis.


Liver Function Tests
1. Total Protein and Albumin/Globulin Ratio:
- Your total protein level is 6.6 g/dL, which falls within the normal range (6.1-7.9 g/dL). However, your globulin level is slightly below the normal range (1.9 g/dL vs. normal 2.0-3.9 g/dL), and your albumin/globulin ratio is elevated at 2.5 (normal is 1.0-1.8).
- A low globulin level can indicate a variety of conditions, including liver disease, kidney disease, or malnutrition. The elevated albumin/globulin ratio may suggest that there is a relative deficiency of globulins, which could be due to liver dysfunction or other underlying conditions.

2. Liver Enzymes:
- Your liver enzymes (GOT, GPT, and r-GT) are all within normal limits, which is a positive sign. Elevated liver enzymes typically indicate liver inflammation or damage, but since yours are normal, it suggests that there is no acute liver injury at this time.

3. Bilirubin Levels:
- Your total bilirubin (T-BILI) is 0.9 mg/dL, which is within the normal range (0.4-1.3 mg/dL). This indicates that your liver is functioning well in terms of processing bilirubin, a waste product from the breakdown of red blood cells.


Urine Analysis
1. Specific Gravity:
- The specific gravity of your urine is >= 1.030, which is higher than the normal range (1.002-1.025). This can indicate concentrated urine, which may result from dehydration, high protein intake, or other factors. Since you mentioned that you performed heavy weight training the day before your test, this could have contributed to dehydration and a higher specific gravity.

2. Urine Protein:
- The presence of urine protein (+/-) indicates that there may be a small amount of protein in your urine. While trace amounts can be normal, significant proteinuria can suggest kidney issues or other systemic conditions. Given your recent exercise, this could also be a temporary finding.

3. Urine Bilirubin:
- The presence of urine bilirubin (1+) is noteworthy. Normally, urine should not contain bilirubin, as it is typically processed by the liver and excreted in bile. A positive result may indicate liver dysfunction or hemolysis (breakdown of red blood cells), which could lead to excess bilirubin in the bloodstream that spills over into the urine.


Summary and Recommendations
Based on your test results, there are some areas of concern, particularly with the low globulin level and the presence of bilirubin in your urine. However, your liver enzymes and bilirubin levels are normal, which is reassuring. The elevated specific gravity and trace protein in your urine could be related to dehydration or exercise.

It is essential to follow up with your healthcare provider for a comprehensive evaluation. They may recommend further testing, such as additional liver function tests, imaging studies, or a 24-hour urine collection to assess protein levels more accurately. Additionally, discussing your recent exercise regimen and hydration status with your doctor can provide further insights into your results.

In conclusion, while there are some abnormal findings, they do not definitively indicate severe liver disease. Monitoring and further evaluation will help clarify your health status and guide any necessary interventions. Always consult with your healthcare provider for personalized medical advice and recommendations based on your specific situation.

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