Abnormal Liver Enzymes: What You Need to Know - Gastroenterology and Hepatology

Abnormal liver function tests?

Dear Dr.
Lin,
I hope this message finds you well.
Recently, the company sent out the health check report for April, and I noticed some abnormalities in my liver function tests, which has caused me some concern.
I would appreciate your assistance in addressing this matter.
The report shows the following abnormal results in red:
- GOT: 41
- GPT: 66
- Globulin: 3.8
- Neutrophil count: 2.9
I recall that one of the liver enzymes, either GOT or GPT, was also flagged in red last year, with values around 40, while the other enzyme was normal.
Last year’s ultrasound examination showed no signs of fatty liver, but this time, it indicates elevated visceral fat.

I usually go to bed around midnight, and I only drink alcohol during company gatherings, which happen every few months, typically consuming about two bottles of beer.
I do not drink alcohol regularly.
Thank you for your attention and for addressing my concerns.
Sincerely,
Little Bamboo

Xiao Zhuzi, 40~49 year old female. Ask Date: 2013/07/09

Dr. Lin Minghui reply Gastroenterology and Hepatology

Abnormal liver function tests, although not significantly elevated, require investigation to determine the cause and to monitor for chronic Hepatitis B or C.
Common causes of liver function abnormalities include fatty liver, alcohol consumption, metabolic syndrome, weight gain, elevated blood sugar, high lipid levels, fatigue, and exposure to chemicals.
Additionally, some less common causes such as autoimmune diseases, metabolic genetic disorders, and systemic diseases can also lead to abnormal liver function tests.
It is recommended to pay attention to diet and lifestyle habits and to undergo regular monitoring.
Best wishes, Dr.
Lin Ming-Hui, Taoyuan Hospital, Department of Health.

Reply Date: 2013/07/09

More Info

Hello, 小竹子!
Thank you for reaching out with your concerns regarding your recent liver enzyme test results. It’s understandable to feel worried when faced with abnormal liver function tests, especially when they have shown elevated levels in the past. Let’s break down what these results mean and what steps you can take moving forward.

Understanding Your Liver Enzyme Results
1. GOT (AST) and GPT (ALT): These enzymes are crucial indicators of liver health. Elevated levels of GOT (41) and GPT (66) suggest that there may be some degree of liver inflammation or damage. Generally, ALT is more specific to liver injury than AST, which can also be elevated in conditions affecting other organs, such as the heart or muscles. Your values indicate a mild elevation; however, consistent monitoring is essential.

2. Globulin Levels: Your globulin level of 3.8 is within the normal range, but it’s important to consider this in the context of your overall health and any other symptoms you may be experiencing.

3. Neutrophil Count: A neutrophil count of 2.9 is generally considered normal, but it’s essential to correlate this with any signs of infection or inflammation.

Possible Causes of Elevated Liver Enzymes
Given your history of elevated liver enzymes and the recent findings, several factors could contribute to these results:
- Non-Alcoholic Fatty Liver Disease (NAFLD): The increase in visceral fat you mentioned could be a contributing factor. NAFLD is common and often linked to obesity, insulin resistance, and metabolic syndrome. It can lead to inflammation and liver damage if not addressed.

- Alcohol Consumption: While you mentioned that you typically do not drink alcohol, even moderate consumption during company gatherings can impact liver health, especially if it occurs frequently.

- Diet and Lifestyle: A diet high in saturated fats, sugars, and processed foods can exacerbate liver issues. Regular exercise and a balanced diet are crucial for maintaining liver health.

Next Steps
1. Follow-Up Testing: It’s advisable to have follow-up blood tests to monitor your liver enzymes. This will help determine if the elevation is persistent or if it was a transient issue.

2. Imaging Studies: Since your previous ultrasound showed no fatty liver, it may be beneficial to repeat this imaging to assess any changes in liver structure or fat accumulation.

3. Lifestyle Modifications: Consider adopting a healthier lifestyle. This includes:
- Diet: Focus on a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Limit saturated fats and sugars.

- Exercise: Aim for at least 150 minutes of moderate aerobic activity per week, which can help reduce visceral fat and improve liver health.

- Hydration: Drink plenty of water and limit sugary drinks.

4. Consultation with a Specialist: If your liver enzymes remain elevated or if you develop any symptoms (such as jaundice, fatigue, or abdominal pain), it may be wise to consult a hepatologist or gastroenterologist for further evaluation.

Conclusion
While elevated liver enzymes can be concerning, they are not uncommon and can often be managed effectively with lifestyle changes and regular monitoring. It’s essential to stay proactive about your health and maintain open communication with your healthcare provider. If you have any further questions or need clarification on any points, please don’t hesitate to reach out.

Take care, and I wish you the best on your journey to better liver health!

Similar Q&A

Understanding Abnormal Liver Function: Causes, Risks, and Solutions

Hello Doctor, I recently had a health checkup at school and found that my liver function is somewhat problematic with GOT at 39 and GPT at 90. My family has a history of liver diseases, and I also tend to stay up late. 1. I would like to ask if there are medications available t...

Dr. Lin Minghui reply Gastroenterology and Hepatology
Hello, Student Lin. 1. When liver function is abnormal, it is important to identify the cause and provide targeted treatment rather than simply controlling the values with medication. In cases of viral hepatitis, types B and C can easily become chronic and require monitoring. C...

Understanding Abnormal Liver Enzymes: Causes and Concerns

Hello, doctor. I have always had a high body weight. In July of this year, I had a blood test that revealed abnormal liver enzyme levels (AST 69 / ALT 147 / GGT 155). The doctor suspected that this might be related to the fact that I had chickenpox in June and took a considerable...

Dr. Chen Shidian reply Gastroenterology and Hepatology
Fatty liver disease, drug-induced/alcoholic hepatitis, and even autoimmune hepatitis are possible conditions that require diagnosis and treatment by a hepatologist. Dietary changes, exercise, weight loss, and abstaining from alcohol are initial steps that can be taken independent...

Understanding Abnormal Liver Enzymes: Causes and Next Steps

Hello Doctor, At the end of February, my school conducted a health check, and the results showed abnormal liver enzyme levels, with GOT at 38 and GPT at 92. In April, I had a follow-up blood test, and my GOT decreased to 82. The healthcare personnel at school informed me that I...

Dr. Chen Shidian reply Gastroenterology and Hepatology
Hello, Miss: The effectiveness of medication for fatty liver is not very good; long-term control of diet and weight is necessary for improvement. Please continue to make an effort and follow up. If there is no family history of hepatitis B or if you are not involved in the health...

Understanding Abnormal Glutamyl Transferase Levels: Causes and Concerns

Hello, I recently had a health check-up at my company and my results showed an abnormal level of gamma-glutamyl transferase (GGT) at 104. The other results were as follows: GTP: 18, SGOT: 23, direct bilirubin (D-BIL): 0.2, total bilirubin (T-BIL): 0.4, hepatitis B surface antigen...

Dr. Lin Minghui reply Gastroenterology and Hepatology
Hello: Gamma-glutamyl transferase (GGT) can be found in biliary epithelial cells, hepatocytes, and other tissues such as the kidneys, pancreas, and small intestine. GGT, also known as the alcohol index, can be used to assess alcoholic hepatitis. Additionally, if alkaline phosphat...