Abnormal Liver Enzymes: Causes and Next Steps - Gastroenterology and Hepatology

Q: Abnormal Liver Enzymes: Causes and Next Steps

Hello, Miss： The effectiveness of medication for fatty liver is not very good; long-term control of diet and weight is necessary for improvement. <br>Please continue to make an effort and follow up. <br>If there is no family history of hepatitis B or if you are not involved in th

Regarding abnormal liver enzyme levels?

Hello Doctor,
At the end of February, my school conducted a health check, and the results showed abnormal liver enzyme levels, with GOT at 38 and GPT at 92.
In April, I had a follow-up blood test, and my GOT decreased to 82.
The healthcare personnel at school informed me that I have fatty liver.
Will this condition improve? Since then, I have lost about 6 kilograms.
Should I undergo further testing? Additionally, the report indicates that I am negative for Hepatitis B surface antigen and antibodies.
What does this mean? Do I need to get vaccinated again? Thank you for your answers.

Nini, 20~29 year old female. Ask Date: 2014/10/16

Dr. Chen Shidian reply Gastroenterology and Hepatology

Hello, Miss: The effectiveness of medication for fatty liver is not very good; long-term control of diet and weight is necessary for improvement.
Please continue to make an effort and follow up.
If there is no family history of hepatitis B or if you are not involved in the healthcare industry (where you might come into contact with hepatitis B patients), it is not recommended to pay out of pocket for an additional vaccination.
Changhua Hospital cares about your health.
Chen Shidian

Reply Date: 2014/10/16

More Info

Hello! It sounds like you have some concerns regarding your liver health based on your recent blood tests and the diagnosis of fatty liver. Let’s break down your questions and provide some clarity.

Understanding Your Liver Enzyme Levels
Your liver enzyme levels, specifically GOT (AST) and GPT (ALT), are indicators of liver health. Elevated levels, such as your initial readings of GOT 38 and GPT 92, suggest that there may be some liver inflammation or damage. The fact that your GOT decreased to 82 in April is a positive sign, indicating that there may be some improvement in your liver function.

Fatty Liver Disease
Fatty liver disease, or hepatic steatosis, is characterized by an excessive accumulation of fat in liver cells. It can be caused by various factors, including obesity, excessive alcohol consumption, certain medications, and metabolic disorders. Since you mentioned losing about 6 kilograms, this weight loss can be beneficial for your liver health, especially if it is part of a broader lifestyle change that includes a balanced diet and regular exercise.

Next Steps for Monitoring
Given your history of elevated liver enzymes and the diagnosis of fatty liver, it is advisable to continue monitoring your liver health. Regular follow-up blood tests can help track your liver enzyme levels and assess any changes. Additionally, an abdominal ultrasound can provide more information about the state of your liver and help determine the extent of fatty changes.

B Hepatitis Antigen and Antibody Status
Regarding your B-type hepatitis antigen and antibody results being negative, this indicates that you are not currently infected with the hepatitis B virus (HBV) and that you do not have immunity against it. In other words, you have not been exposed to the virus or vaccinated against it.

Vaccination Considerations
Since you are negative for both the hepatitis B surface antigen (HBsAg) and the hepatitis B surface antibody (anti-HBs), it is recommended that you consider getting vaccinated against hepatitis B. The vaccine is safe and effective, and it can provide you with immunity against the virus, which is particularly important if you are at risk of exposure.

Conclusion
In summary, it is essential to continue monitoring your liver health through regular check-ups and blood tests. Weight loss and lifestyle changes can significantly improve fatty liver conditions. Additionally, consider getting vaccinated against hepatitis B to protect yourself from potential infection. If you have any further concerns or if your liver enzyme levels do not improve, it would be wise to consult with a hepatologist or a gastroenterologist for a more comprehensive evaluation and management plan.

Take care of your health, and don’t hesitate to reach out to your healthcare provider for any further questions or concerns!

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