Do I Have Gout? Diagnosis and Medication Options - Internal Medicine

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Do I really have gout? Should I take these medications?


Dear Doctor,
I have a condition of elevated uric acid levels (it reached 10.2 two years ago, 8.7 three months ago, and currently 8.8).
My blood pressure fluctuates between normal and slightly high (not frequently monitored).
Sometimes I experience pain in my toes, but there is no redness or swelling.
Recently, I visited a hospital where the doctor diagnosed me with "idiopathic gout" and prescribed a 30-day supply of medication (Colchicine 0.5 mg twice daily, one tablet each time; Zyloric 100 mg once daily, one tablet).
I was instructed to return for a follow-up in a month, but the doctor did not inform me about potential side effects of the medications; I found out about them through my own research.
I would like to ask: In the absence of joint fluid aspiration or arthroscopy to confirm my gout diagnosis, am I required to take these medications? Why am I being prescribed these medications now? Under what circumstances would a doctor consider performing joint fluid aspiration or arthroscopy (as I am concerned about misdiagnosis)? Are there specific specialties of doctors who perform joint fluid aspiration or arthroscopy? Which procedure is preferable, joint fluid aspiration or arthroscopy? I would appreciate your advice.
Thank you!

Erick, 30~39 year old female. Ask Date: 2002/05/10

Dr. Liu Hongxiang reply Internal Medicine


Gout is caused by the deposition of uric acid crystals in the joints, leading to acute arthritis, and the higher the uric acid levels, the greater the likelihood of developing gout.
Symptoms typically manifest as swelling, redness, heat, and pain in a single joint.
The first two days are usually the most severe, after which the swelling and pain gradually improve.
The big toe is the most commonly affected joint, and the symptoms are characteristic of gout.
If hyperuricemia is present and colchicine is effective, joint aspiration may not be necessary; however, if there is uncertainty, arthroscopy may be performed to check for gout crystals.

During the acute phase, colchicine and non-steroidal anti-inflammatory drugs (NSAIDs) can effectively reduce swelling and pain.
In the chronic phase, if gout is present, urate-lowering medications can be used to prevent attacks.
If there is only hyperuricemia without gout, dietary and exercise modifications should be the first approach.
Based on your description, it seems you may have chronic gout, and urate-lowering medications can be considered.
If there are doubts or atypical symptoms, joint aspiration (by orthopedic or rheumatology specialists) may be warranted.
Generally, aspiration can confirm the presence of gout crystals without the need for arthroscopy.

Reply Date: 2002/05/10

More Info


Gout is a form of inflammatory arthritis characterized by sudden and severe pain, redness, and swelling in the joints, often affecting the big toe. It is caused by the accumulation of uric acid crystals in the joints, which can occur when there is an excess of uric acid in the blood, a condition known as hyperuricemia. Your reported uric acid levels, which have fluctuated between 8.7 and 10.2 mg/dL, indicate that you are indeed experiencing hyperuricemia, as normal levels are typically below 6.0 mg/dL for women and 7.0 mg/dL for men.

The symptoms you describe, such as occasional pain in your toe without redness or swelling, may suggest a condition known as "asymptomatic hyperuricemia" or "subclinical gout." In some cases, individuals with elevated uric acid levels may not experience any symptoms, while others may have intermittent episodes of pain. The term "unclassified gout" used by your physician likely refers to the absence of definitive clinical signs of gout, such as the classic acute attack with swelling and redness, but acknowledges the potential for gout given your elevated uric acid levels.

The medications prescribed to you, Colchicine and Zyloric (Allopurinol), are commonly used to manage gout. Colchicine is an anti-inflammatory medication that helps alleviate pain during acute gout attacks, while Allopurinol is a urate-lowering therapy that reduces uric acid production in the body. The goal of Allopurinol is to prevent future gout attacks by maintaining uric acid levels within a normal range. It is important to note that while these medications can be effective, they may also have side effects, including gastrointestinal upset, liver function abnormalities, and, in rare cases, severe allergic reactions.

Regarding your concerns about the necessity of joint aspiration (arthrocentesis) or arthroscopy, these procedures are typically performed to obtain synovial fluid from the joint for analysis. Joint aspiration can help confirm a diagnosis of gout by identifying the presence of uric acid crystals in the fluid. It is often considered when a patient presents with classic symptoms of gout or when there is uncertainty about the diagnosis. Arthroscopy, on the other hand, is a more invasive procedure that allows for direct visualization of the joint and is usually reserved for more complex cases where other conditions need to be ruled out.

In your case, if your symptoms are mild and infrequent, your physician may choose to manage your condition with medication rather than performing invasive procedures. However, if you experience more severe symptoms or if there is uncertainty about the diagnosis, your physician may recommend joint aspiration to provide clarity. Typically, rheumatologists are specialists who manage gout and perform joint aspirations, but orthopedic surgeons may also perform arthroscopy if necessary.

In conclusion, while you may not have undergone joint aspiration or arthroscopy, your physician's decision to prescribe medication is based on your elevated uric acid levels and the potential for gout. It is essential to follow up with your healthcare provider as recommended, and if you have concerns about the medications or the diagnosis, do not hesitate to discuss them during your next appointment. Managing gout effectively often involves lifestyle modifications, such as dietary changes, weight management, and regular monitoring of uric acid levels, in addition to medication.

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