Concerns About Administering Four-in-One Vaccine in the Buttocks - Pediatrics

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Four-in-One Booster Vaccine by Pasteur


The child is 6 years and 1 month old.
Today, they were taken to the clinic to receive the booster dose of the Pentavalent vaccine (DTPaHibIPV) and the Japanese Encephalitis vaccine, both administered in the buttocks (one injection in each side).
Upon returning home, I noticed that the information sheet for the Pentavalent booster vaccine states "should not be administered in the buttocks." I am concerned about any potential side effects.
Additionally, the child still needs to receive the second dose of the MMR vaccine.
What is the recommended interval between administering the MMR vaccine and the previously mentioned vaccines? What is the suggested injection site for the MMR vaccine?

Lucy, 30~39 year old female. Ask Date: 2013/05/15

Dr. Xiao Kaiwen reply Pediatrics


Vaccines are not suitable for administration in the buttocks, particularly for children under three years old, as the gluteal muscles are not sufficiently developed at that age.
By the age of six, it should be acceptable.
There is no specific time interval required between vaccinations; however, if they are scheduled too closely together, different injection sites, such as the deltoid muscle in the upper arm, can be used.

Reply Date: 2013/05/15

More Info


When it comes to administering vaccines, the site of injection is crucial for both efficacy and safety. The concerns you raised about administering the Pasteur four-in-one vaccine and Japanese encephalitis vaccine in the buttocks are valid, especially since the manufacturer's guidelines recommend against this practice.

Risks of Administering Vaccines in the Buttocks
1. Absorption Issues: Vaccines are typically administered in the deltoid muscle of the upper arm or the vastus lateralis muscle of the thigh for children. These sites have a rich blood supply, which facilitates better absorption of the vaccine into the bloodstream. The buttocks, particularly the gluteal muscle, may not provide the same level of absorption, potentially leading to reduced vaccine efficacy.

2. Nerve Damage: The buttocks contain major nerves, including the sciatic nerve. Injecting into this area carries a risk of nerve injury, which can lead to pain, numbness, or weakness in the leg.

3. Local Reactions: While local reactions such as pain, swelling, or redness can occur at any injection site, the buttocks may be more prone to complications like abscess formation if the injection technique is not sterile.

4. Post-Injection Monitoring: Vaccines administered in the buttocks may not be as easily monitored for immediate reactions compared to those given in the arm, where caregivers can easily observe the injection site.


Recommendations for Future Vaccinations
Given your child's age and the vaccines administered, it is essential to follow up with the healthcare provider regarding any potential side effects or complications. If your child experiences unusual symptoms such as prolonged pain, swelling, or any signs of an allergic reaction, seek medical attention promptly.

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Timing for MMR Second Dose
The MMR (measles, mumps, rubella) vaccine is typically administered in two doses. The first dose is usually given between 12 to 15 months of age, and the second dose is given between 4 to 6 years of age. Since your child is currently 6 years and 1 month old, it is appropriate to administer the second dose of MMR now if it has not been given yet.
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Recommended Injection Sites
For the MMR vaccine, the recommended injection site is the deltoid muscle of the upper arm for children over 1 year of age. This site is preferred due to its accessibility, the ability to monitor for immediate reactions, and the rich blood supply that aids in vaccine absorption.


Conclusion
In summary, while administering the Pasteur four-in-one vaccine and Japanese encephalitis vaccine in the buttocks may not lead to immediate adverse effects, it is not the recommended practice and could potentially compromise vaccine efficacy. It is advisable to consult with your healthcare provider about the situation and ensure that future vaccinations, including the MMR second dose, are administered in the appropriate sites for optimal safety and effectiveness. Always keep an eye on your child for any unusual symptoms following vaccination and maintain open communication with your healthcare provider regarding any concerns.

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