Does Undigested Food Affect Fecal Occult Blood Test Results? - Gastroenterology and Hepatology

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Fecal occult blood test (FOBT)


I would like to ask the doctor, if during a fecal occult blood test, the stool sample contains undigested food residues such as chili flakes, could this lead to a false positive result? Thank you, and happy New Year!

Hui, 40~49 year old female. Ask Date: 2014/02/06

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: The more commonly used methods for fecal occult blood testing are: (1) chemical methods; and (2) immunochemical methods.
The chemical method is more susceptible to interference from certain foods or medications (including peroxidase).
Foods that can easily cause false positives include: red meat, fish (salmon, sardines), poultry, cauliflower, turnips, broccoli, and radishes.
Medications such as iron supplements and aspirin can also cause interference.
The immunochemical method is more specific and less affected by diet.
Although the residue from chili peppers may appear red, it should not cause interference.
If the immunochemical method is used, it is even less likely to be affected.
Changhua Hospital cares about your health.
Dr.
Tsai An-shun.

Reply Date: 2014/02/06

More Info


The fecal occult blood test (FOBT) is a crucial screening tool used to detect hidden blood in the stool, which can be an indicator of various gastrointestinal conditions, including polyps, ulcers, and cancers. Your question regarding whether undigested food, such as chili residue, can affect the results of this test is quite pertinent.

To begin with, it's essential to understand the two primary methods used for the FOBT: the chemical method and the immunochemical method. The chemical method is more susceptible to dietary influences, which can lead to false positives. Foods that are known to cause such reactions include red meats, certain fish, and some vegetables like broccoli and cauliflower. These foods contain substances that can mimic the presence of blood when the test is conducted. In contrast, the immunochemical method is more specific and generally less affected by dietary intake, making it a preferred choice in many clinical settings.

Regarding your specific concern about chili residue, while it is true that the bright red color of undigested food could potentially raise concerns about false positives, the actual impact of chili or similar foods on the FOBT results is less clear. Most studies suggest that the primary culprits for false positives are those foods that contain heme iron, which is found in red meat and certain fish. Chili peppers, while they may cause a change in stool color, do not typically contain substances that would interfere with the test in the same way.

However, if you have consumed a significant amount of these foods shortly before the test, it is advisable to inform your healthcare provider. They may recommend avoiding certain foods for a few days prior to the test to minimize the risk of false positives.
In terms of your overall health and the results of your tests, if you have undergone the FOBT and received normal results, it is generally a good indication that there is no significant gastrointestinal bleeding. If you have a history of gastrointestinal issues, such as irritable bowel syndrome (IBS), it is also important to consider that these conditions can cause changes in bowel habits and stool appearance, which may lead to confusion regarding test results.

If you experience any unusual symptoms, such as persistent changes in stool color, abdominal pain, or changes in bowel habits, it is crucial to consult with a healthcare professional. They may recommend further testing, such as a colonoscopy, especially if there are any concerns about the possibility of underlying conditions.

In conclusion, while undigested food like chili residue is unlikely to cause a false positive in the FOBT, it is always best to follow dietary guidelines provided by your healthcare provider before undergoing such tests. If you have any concerns about your health or test results, do not hesitate to reach out for further evaluation and guidance. Wishing you good health and a happy new year!

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