Managing Liver Health: Addressing Fatty Liver and Cholesterol Concerns - Gastroenterology and Hepatology

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Hello, I have been a carrier of hepatitis C for a long time, and I have not undergone treatment due to concerns about the side effects.
My AST levels are normal, and my ALT levels are mostly below 60.
However, I have fatty liver and high cholesterol.
I go for regular follow-ups every three months.
After losing seven kilograms, my fatty liver has improved, but my cholesterol remains high (233) despite my efforts to reduce oil intake.
Should I ask my doctor to prescribe cholesterol-lowering medication? Additionally, my recent test showed abnormal ceruloplasmin levels (+), but when I visited the metabolism department, they did not find any signs of diabetes (they did not test for ketones).
Could this be related to my fasting for fifteen hours before the blood test? Should I go back to the metabolism department for another test? Thank you.

Xiao Ye, 30~39 year old female. Ask Date: 2014/02/17

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello: 1.
Fatty liver and high cholesterol require long-term dietary weight control and exercise to see results.
The use of cholesterol-lowering medications must be evaluated before use.
2.
Prolonged fasting can lead to the production of ketones.
3.
For chronic hepatitis C and abnormal GPT levels, the current treatment primarily involves long-acting interferon and ribavirin, which have an efficacy of over 70%.
Obesity can affect treatment efficacy.
Controlling cholesterol and blood sugar, along with moderate exercise, can improve fatty liver; however, if there is hepatitis C virus present in the blood and GPT levels remain abnormal, treatment with interferon and ribavirin is still recommended to eliminate the virus and reduce inflammation.
Sincerely, Dr.
Lin Ming-Hui, Gastroenterology Department, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2014/02/17

More Info


Managing liver health, particularly in the context of fatty liver disease and elevated cholesterol levels, is a multifaceted approach that requires careful consideration of diet, lifestyle changes, and medical management. Given your history of being a chronic hepatitis C carrier, it is understandable that you have concerns about treatment side effects. However, managing your liver health is crucial, especially in the presence of fatty liver and high cholesterol.


Understanding Fatty Liver and Cholesterol
Fatty liver disease, or hepatic steatosis, occurs when excess fat builds up in the liver. It can be associated with various factors, including obesity, insulin resistance, and high cholesterol levels. Elevated cholesterol, particularly low-density lipoprotein (LDL), can contribute to cardiovascular disease and may also exacerbate liver conditions.

Your recent weight loss of seven kilograms is a positive step, as weight reduction is one of the most effective strategies for improving fatty liver. However, the persistence of high cholesterol levels despite dietary changes can be frustrating. It is essential to recognize that cholesterol levels can be influenced by various factors, including genetics, metabolism, and dietary habits.


Dietary Recommendations
1. Balanced Diet: Focus on a diet rich in whole foods, including fruits, vegetables, whole grains, lean proteins, and healthy fats. Foods high in fiber, such as oats, legumes, and vegetables, can help lower cholesterol levels.

2. Limit Saturated and Trans Fats: Reduce your intake of saturated fats found in red meat and full-fat dairy products, and avoid trans fats found in many processed foods. Instead, incorporate healthy fats from sources like avocados, nuts, seeds, and olive oil.

3. Increase Omega-3 Fatty Acids: Foods rich in omega-3 fatty acids, such as fatty fish (salmon, mackerel), flaxseeds, and walnuts, can help improve liver health and lower triglycerides.

4. Stay Hydrated: Drinking plenty of water is essential for overall health and can aid in liver function.

5. Limit Sugar and Refined Carbohydrates: Reducing sugar intake and avoiding refined carbohydrates can help manage both fatty liver and cholesterol levels.


Medical Management
Given that your cholesterol remains elevated at 233 mg/dL despite dietary changes, it may be appropriate to discuss medication options with your healthcare provider. Statins are commonly prescribed to lower cholesterol levels and can be beneficial for individuals with fatty liver disease. However, the decision to start medication should be made collaboratively with your doctor, considering your overall health, liver function, and any potential interactions with your hepatitis C status.


Follow-Up Testing
Regarding the abnormal copper levels detected in your blood tests, it is essential to follow up with your healthcare provider. The presence of copper in the blood can indicate conditions such as Wilson's disease, but it can also be influenced by dietary factors and the timing of your blood tests. Fasting before blood tests can sometimes affect results, so it may be worthwhile to repeat the tests under controlled conditions.


Conclusion
Managing liver health, especially with a background of chronic hepatitis C, fatty liver, and high cholesterol, requires a comprehensive approach that includes lifestyle modifications, dietary adjustments, and regular medical follow-up. Continue to monitor your liver function and cholesterol levels closely with your healthcare provider, and do not hesitate to seek further evaluation if you have concerns about your copper levels or any other health issues. Remember, proactive management can significantly improve your liver health and overall well-being.

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