Kidney Issues: Proteinuria and Rising Creatinine Levels - Internal Medicine

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Regarding kidney disease issues?


Three months ago, blood tests showed a creatinine level of 1.0 mg/dL and a BUN of 7.2 mg/dL.
Three days ago, blood tests indicated that the creatinine level has risen to 1.1 mg/dL, and a urinalysis revealed proteinuria at 10 mg.
In recent months, there have been symptoms of proteinuria, with morning urine being darker in color and having more foam, although this foam disappears after increased water intake.
What could be the possible issue? Thank you, Dr.
Wu.

AIR, 20~29 year old female. Ask Date: 2014/03/19

Dr. Wu Jiyu reply Internal Medicine


Three months ago, blood tests showed a creatinine level of 1.0, which corresponds to an estimated glomerular filtration rate (eGFR) of 98 ml/min/1.73m².
Three days ago, the creatinine level increased to 1.1, resulting in an eGFR of 88 ml/min/1.73m².
Although this appears to be a decline of 10 ml/min/1.73m², clinical significance requires long-term monitoring.
Regarding the proteinuria of 10 mg, it does not exceed 150 mg/g, which is still considered normal.
Please do not use "darker urine with more bubbles in the morning, which disappears after drinking more water" as a criterion for determining proteinuria; all assessments should be based on laboratory reports.
Thank you for your inquiry.
The Nephrology Department at Changhua Hospital is here to support you.

Reply Date: 2014/03/19

More Info


Understanding kidney issues, particularly proteinuria and rising creatinine levels, is crucial for maintaining kidney health. Based on your recent lab results and symptoms, it appears that you may be experiencing early signs of kidney dysfunction, which warrants further investigation and monitoring.

Your blood tests show a slight increase in creatinine from 1.0 to 1.1 mg/dL, which is still within a relatively normal range but indicates a trend that should be observed. The BUN (Blood Urea Nitrogen) level of 7.2 mg/dL is also within normal limits, suggesting that your kidneys are still functioning adequately in terms of waste removal. However, the presence of proteinuria (10 mg) in your urine is concerning, especially since you have noted symptoms such as darker urine and increased foaming, which can be indicative of protein in the urine.

Proteinuria can arise from various causes, including transient conditions such as dehydration, intense physical activity, or even stress. However, persistent proteinuria can indicate underlying kidney issues, such as glomerulonephritis, diabetic nephropathy, or hypertension-related kidney damage. The fact that you have noticed foamy urine, particularly in the morning, could suggest that protein is being excreted in larger amounts than normal, which may be a sign of kidney stress or damage.

The increase in creatinine levels, albeit slight, alongside the presence of protein in your urine, suggests that your kidneys may be under some strain. It is essential to consider factors that could contribute to these changes. For instance, if you have been engaging in high-intensity workouts or consuming a high-protein diet, these could temporarily elevate creatinine levels and lead to proteinuria. However, if these lifestyle factors are not present, it becomes increasingly important to investigate further.

Given your symptoms and lab results, I recommend the following steps:
1. Hydration: Continue to ensure you are well-hydrated, as dehydration can concentrate urine and lead to misleading results in urine tests. Drinking plenty of water can help dilute the urine and may reduce the appearance of protein.

2. Dietary Considerations: If you are consuming a high-protein diet, consider moderating your protein intake. While high protein diets can be beneficial for muscle building, they may place additional stress on the kidneys, especially if there is an underlying issue.

3. Regular Monitoring: Schedule regular follow-up appointments with your healthcare provider to monitor your kidney function. This includes repeat blood tests for creatinine and BUN, as well as urine tests for protein levels. Tracking these values over time will help determine if there is a significant decline in kidney function.

4. Further Testing: If proteinuria persists or worsens, your doctor may recommend additional tests, such as a 24-hour urine collection for protein, urine microalbumin tests, or imaging studies to assess kidney structure. In some cases, a kidney biopsy may be necessary to determine the underlying cause of kidney dysfunction.

5. Consult a Specialist: If your primary care physician is concerned about your kidney function, they may refer you to a nephrologist (kidney specialist) for further evaluation and management.

In conclusion, while your current lab results do not indicate severe kidney dysfunction, the presence of proteinuria and a slight increase in creatinine levels should not be ignored. By taking proactive steps to monitor your kidney health and making necessary lifestyle adjustments, you can help protect your kidneys and maintain overall health. Always consult with your healthcare provider for personalized advice and treatment options based on your specific situation.

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