Calcium Channel Blockers: Safety, Dosage, and Concerns - Cardiology

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Calcium channel blockers


Hello Dr.
He, I am currently undergoing treatment for coronary heart disease.
During my follow-up appointment yesterday, my doctor discontinued "Kankun" 10 mg (to be taken once daily) and switched me to "Cardizem SR" 90 mg (to be taken once daily).
Since these two medications are completely different and the dosages vary significantly, I am a bit concerned.
This morning, I tried taking "Cardizem SR," and about an hour and a half later, I experienced dizziness and facial flushing.
At first, I thought I had a fever, but that was not the case (I did not have such symptoms with Kankun).

Additionally, I am worried that the traditional Chinese medicine I am currently taking might interact with "Cardizem SR." Furthermore, my mother has been taking "Cardizem SR" for many years, and her kidney function was found to be problematic during a check-up at Chang Gung Memorial Hospital.
I am unsure if there is any correlation.
Some information suggests that short-acting calcium channel blockers raise concerns regarding kidney function (the same applies to long-acting ones).
After reviewing a lot of information, I feel that calcium channel blockers should be used with caution.
Of course, if patients act like they know everything, then what’s the point of doctors studying for so many years? Therefore, I still need to consult Dr.
He's expertise as the standard.
Haha...
Thank you!

Mr. Zhang, 50~59 year old female. Ask Date: 2015/02/10

Dr. He Dongjin reply Cardiology


Hello, I am not sure why the medication needs to be adjusted.
You can discuss this with your physician.
Generally, taking 10 mg of Concor (Bisoprolol) will definitely slow down the heart rate.
It is possible that the doctor thinks it is too slow, which is why the adjustment is being made.
However, Bisoprolol, as a selective beta-blocker, has a strong affinity for its receptors.
The process of switching medications can be uncomfortable, including symptoms like palpitations, flushing, and warmth.
These symptoms may also be side effects of calcium channel blockers.
However, you are on a relatively low dose of 90 mg, and this adjustment is actually a reduction in dosage.
Calcium channel blockers are generally considered to be safer than beta-blockers and have fewer side effects.
In hypertension treatment guidelines, they are listed before beta-blockers.
I do not believe your mother's kidney condition is related to this medication.
Currently, the global usage of calcium channel blockers far exceeds that of beta-blockers, and their safety is well established, so there is no need to worry.
Changhua Hospital cares about you.

Reply Date: 2015/02/10

More Info


Calcium channel blockers (CCBs) are a class of medications commonly used to treat various cardiovascular conditions, including hypertension and coronary artery disease. They work by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, leading to vasodilation and decreased heart rate. While these medications can be effective, they also come with potential side effects and considerations, especially when switching from one medication to another, as you have experienced.

In your case, you mentioned switching from "康肯" (likely referring to a specific CCB) to "凱帝心徐放錠" (which is likely a long-acting formulation of a CCB). The significant difference in dosage and formulation can indeed lead to different side effects. The symptoms you experienced—dizziness and facial flushing—are not uncommon with CCBs, especially when starting a new medication or adjusting the dose. These side effects can occur as your body adjusts to the new medication, and they may subside over time. However, if they persist or worsen, it is essential to consult your healthcare provider.

Regarding your concern about potential interactions between "凱帝心徐放錠" and any traditional Chinese medicine (TCM) you may be taking, it is crucial to inform your healthcare provider about all medications and supplements you are using. Some herbal remedies can interact with conventional medications, either enhancing their effects or causing adverse reactions. For example, certain herbs may affect liver enzymes that metabolize medications, leading to altered drug levels in the body. Always discuss any TCM or supplements with your doctor to ensure safe and effective treatment.

As for your mother's long-term use of "凱帝心徐放錠" and her kidney issues, there is some evidence suggesting that long-term use of CCBs may have implications for renal function, particularly in patients with pre-existing kidney conditions. While CCBs are generally considered safe for most patients, monitoring kidney function is essential, especially in those with risk factors or existing kidney disease. If your mother has been diagnosed with kidney problems, it would be prudent for her healthcare provider to evaluate her medication regimen and consider any necessary adjustments.

In summary, while CCBs can be effective for managing cardiovascular conditions, it is essential to approach their use with caution, particularly when switching medications or combining them with other treatments. Regular follow-up with your healthcare provider is vital to monitor for side effects, assess kidney function, and ensure that all aspects of your treatment plan are safe and effective. Always prioritize open communication with your healthcare team to address any concerns and optimize your treatment outcomes.

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