Misdiagnosis of HPV: Risks and Testing Options - Urology

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HPV misdiagnosis???


Hello Doctor,
I have some questions regarding my girlfriend who has a Bartholin gland cyst.
Recently, it recurred, and she went to a gynecology clinic for examination and treatment.
The doctor visually identified two small protrusions and diagnosed her with HPV infection, recommending a Pap smear (not HPV DNA testing).
I had sexual relations with my girlfriend about three months ago, and she had no prior sexual experience.
During my previous relationship, I also had a single sexual partner and was single for over a year (without sexual activity) before dating my current girlfriend.
I have always been healthy and have never shown any signs of genital warts.
1.
Given the above conditions, what is the likelihood that my girlfriend has genital warts?
2.
Furthermore, is it reasonable for a gynecologist to diagnose genital warts based solely on visual inspection of small protrusions without conducting HPV DNA testing? I have always been cautious about my sexual health, and I feel confused and guilty that my girlfriend, whom I had sex with for the first time, has been diagnosed with HPV.
I have also found several cases online where individuals underwent treatment for genital warts and later discovered it was a misdiagnosis.

To find peace of mind, I plan to take my girlfriend to another gynecology clinic for a consultation and to undergo HPV DNA testing.

3.
Will HPV DNA testing provide a definitive confirmation of whether she has genital warts? How long does it typically take to receive the results?
4.
Additionally, would you recommend that women see a gynecologist or a urologist for such issues? A single statement from a physician can have a significant psychological impact on patients, especially regarding these types of symptoms.
I have spent a lot of time researching this topic and would greatly appreciate your thoughts and recommendations.
Thank you very much!

A-Bao, 20~29 year old female. Ask Date: 2015/03/01

Dr. Xu Weikai reply Urology


A-Bao: Hello! 1.
Warts, also known as condylomata acuminata, are just one manifestation of the many types of HPV (human papillomavirus).
Generally, diagnosis is made visually.
If there is uncertainty, additional tests such as biopsy, blood tests, or DNA testing may be required.
2.
The global prevalence of HPV among women is approximately one in ten.
3.
Blood tests and DNA testing cannot confirm HPV with 100% certainty.
4.
If you have concerns, you can check online: Taiwan Cancer Foundation, which provides detailed information about HPV.
5.
It is more appropriate for women to seek care from an obstetrician-gynecologist.
If there are any unclear points, feel free to ask again, and we can discuss and research further.
Online responses should only be used as a reference; it is still necessary to seek care at a medical institution.
The Ministry of Health and Welfare Taitung Hospital cares about you.

Reply Date: 2015/03/01

More Info


The concerns surrounding HPV (Human Papillomavirus) infections, particularly regarding misdiagnosis and testing options, are valid and warrant careful consideration. Let's break down your questions and provide a comprehensive understanding of HPV, its transmission, testing methods, and the implications of diagnosis.

1. Risk of HPV Infection: Given your description, the likelihood of your girlfriend having HPV, particularly if she has had no prior sexual experience, is relatively low. HPV is primarily transmitted through skin-to-skin contact during sexual activity. If you have had only one sexual partner before her and have been symptom-free, it reduces the risk of transmission. However, it's important to note that HPV can remain dormant for years, and some strains can be asymptomatic. Therefore, while the risk may be low, it is not zero.

2. Diagnosis Process: The diagnosis of HPV based solely on a visual examination of small bumps can be problematic. While healthcare providers can sometimes identify warts (condyloma) through visual inspection, a definitive diagnosis of HPV typically requires molecular testing, such as HPV DNA testing. This test can identify the presence of high-risk HPV strains and provide a clearer picture of the infection status. Relying solely on visual inspection without further testing may lead to misdiagnosis, as many skin conditions can mimic the appearance of HPV warts.

3. HPV DNA Testing: HPV DNA testing is a reliable method to confirm the presence of HPV. It can detect the virus even in the absence of visible symptoms. The results from HPV DNA testing usually take about one to two weeks, depending on the laboratory. While this test is not 100% foolproof, it is one of the most accurate methods available for diagnosing HPV infections. If your girlfriend undergoes this test and it returns negative, it can provide significant reassurance.

4. Choosing the Right Specialist: For HPV-related concerns, it is generally advisable for women to consult a gynecologist. Gynecologists specialize in female reproductive health and are well-equipped to handle HPV testing, diagnosis, and treatment. Urologists primarily focus on male urinary tract and reproductive health, so they may not be as familiar with HPV-related issues in women.

5. Addressing Psychological Impact: It is understandable that a diagnosis of HPV can lead to anxiety and guilt, especially when it involves a new partner. It is crucial to communicate openly with your girlfriend about your concerns and feelings. Encourage her to seek a second opinion from another gynecologist, as you mentioned, to ensure that she receives a thorough evaluation and appropriate care. This can help alleviate some of the psychological burden associated with the diagnosis.

6. Preventive Measures: Regardless of the current situation, it is advisable for both partners to consider getting vaccinated against HPV if they haven't already. The HPV vaccine is effective in preventing the most common and high-risk strains of the virus, significantly reducing the risk of developing HPV-related cancers and genital warts.

In conclusion, while the initial diagnosis may seem alarming, it is essential to approach the situation with a clear understanding of HPV transmission, testing, and treatment options. Seeking further testing and a second opinion can provide clarity and peace of mind. Open communication with your partner and proactive health measures will also contribute to a healthier relationship moving forward.

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