Persistent Bleeding After Taking Dailian: What You Need to Know - Obstetrics and Gynecology

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Prolonged bleeding after taking Diane (Diane-35) contraceptive pills?


Previously, an ultrasound pelvic examination revealed the presence of a uterine fibroid located in the middle of the uterus.
The doctor prescribed Diane (Diane-35), instructing me to start taking it on the first day of my menstrual cycle and to begin the second pack with the next menstrual period.
However, for four to five months, I experienced continuous bleeding, with only slightly reduced flow during non-menstrual periods, and sometimes bleeding resumed within less than a week.
Eventually, I decided to stop the medication after finishing the fifth pack.

Later, I consulted a different physician and explained my previous situation.
The doctor prescribed a week’s supply of estrogen and progesterone, advising me to take them and then start Diane on the fifth day after my menstrual period.
However, after stopping for just one day following the end of my menstrual cycle, I began bleeding again.
I am uncertain whether I should continue taking the medication given the ongoing bleeding.
Is this situation concerning?

CRIMSON, 30~39 year old female. Ask Date: 2015/04/10

Dr. Lin Manying reply Obstetrics and Gynecology


Could you clarify whether you started taking Diane after your menstrual period ended and then experienced bleeding again after one day? It is advisable to visit a clinic for an examination and consultation to determine your treatment situation.

Reply Date: 2015/04/10

More Info


Persistent bleeding after taking Dailian (Diane-35) can be concerning, especially when it continues for an extended period. Dailian is a combination hormonal contraceptive that contains ethinyl estradiol and cyproterone acetate, and it is often prescribed for conditions like polycystic ovary syndrome (PCOS), endometriosis, and to manage symptoms associated with uterine fibroids. However, the side effects can include irregular bleeding or spotting, especially during the initial months of use.

In your case, the persistent bleeding you experienced over four to five months could be attributed to several factors. First, hormonal contraceptives can cause changes in the menstrual cycle, particularly in the early stages of treatment. Some women may experience breakthrough bleeding or prolonged bleeding as their bodies adjust to the hormones. This is often more pronounced in women who have underlying conditions such as uterine fibroids, which can also contribute to abnormal bleeding patterns.

When you switched to a new physician and were prescribed estrogen and progesterone, it was likely an attempt to stabilize your hormonal levels and address the ongoing bleeding. The recommendation to start Dailian again after your period was intended to help regulate your cycle. However, if you experienced bleeding shortly after stopping the pill, it could indicate that your body is still adjusting to the hormonal changes or that the underlying issue (such as the fibroids) is still affecting your menstrual cycle.

It's essential to monitor your symptoms closely. If the bleeding is heavy, prolonged, or accompanied by other symptoms such as severe pain, dizziness, or fatigue, you should seek medical attention promptly. Continuous bleeding can lead to anemia, which is a decrease in red blood cells due to blood loss, and may require further evaluation and treatment.

Regarding whether to continue taking Dailian, it is crucial to consult with your healthcare provider. They may recommend further investigations, such as an ultrasound, to assess the status of the uterine fibroids and determine if they are contributing to the bleeding. Depending on the findings, your doctor may suggest alternative treatments, which could include adjusting your hormonal therapy, considering non-hormonal options, or even surgical interventions if the fibroids are significantly impacting your quality of life.

In summary, while it is not uncommon to experience irregular bleeding with hormonal contraceptives, persistent or heavy bleeding warrants further evaluation. Communication with your healthcare provider is key to finding the right treatment plan for your specific situation. They can provide guidance on whether to continue with Dailian or explore other options based on your symptoms and medical history.

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