Does Beta-Blocker Eye Drops Cause Hair Loss? Exploring the Connection - Ophthalmology

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Beta-blockers can cause hair loss?


I have been using Combigan for about five months, and recently I noticed that my hair has become sparse.
My hair used to be normal.
I consulted a dermatologist, and the doctor mentioned that it could be androgenetic alopecia or stress-induced hair loss.
When I was diagnosed with elevated intraocular pressure, I did experience significant anxiety for two to three months, so that could also be a contributing factor.
I found online that beta-blockers can have a risk of causing hair loss.
I would like to ask, what is the likelihood that hair loss is caused by the beta-blocker eye drops? Have doctors observed such cases in clinical practice?

Youhu, 20~29 year old female. Ask Date: 2015/06/03

Dr. He Jianxian reply Ophthalmology


Basically, there have been no cases like this, so I cannot make any assumptions about whether your hair loss is related to beta-blockers.

Reply Date: 2015/06/03

More Info


Beta-blocker eye drops, such as those found in medications like Combigan, are primarily used to manage conditions like glaucoma and ocular hypertension by reducing intraocular pressure. While these medications are effective for their intended purposes, there has been some discussion in the medical community regarding their potential side effects, including hair loss.

To address your concern, it is important to clarify that while systemic beta-blockers (oral medications) have been associated with hair loss in some patients, the connection between topical beta-blocker eye drops and hair loss is less clear. The mechanism by which systemic beta-blockers might contribute to hair loss is thought to be related to their effects on blood circulation and hormonal levels, particularly in relation to androgens, which can influence hair growth cycles. However, the concentration of beta-blockers in eye drops is significantly lower than that of oral medications, which may limit their systemic effects.

In clinical practice, there have been anecdotal reports of hair loss in patients using topical beta-blockers, but these cases are not well-documented in the literature. The incidence of hair loss specifically attributed to beta-blocker eye drops is considered to be rare. Other factors, such as stress, hormonal changes, and underlying conditions like androgenetic alopecia (male or female pattern baldness), can also contribute to hair thinning and loss. Given that you mentioned experiencing significant anxiety and stress related to your eye condition, it is plausible that these psychological factors could be playing a more substantial role in your hair loss than the eye drops themselves.

If you are concerned about the hair loss you are experiencing, it would be prudent to discuss this with your healthcare provider. They may consider evaluating other potential causes of hair loss, including hormonal imbalances, nutritional deficiencies, or other medical conditions. Additionally, if you suspect that the beta-blocker eye drops might be contributing to your hair loss, your doctor may explore alternative treatments for managing your ocular condition that do not carry the same risk.

In summary, while there is a theoretical possibility that beta-blocker eye drops could contribute to hair loss, the evidence supporting this connection is limited. It is essential to consider other factors that may be influencing your hair health. Regular follow-ups with your healthcare provider can help monitor your condition and address any concerns you may have regarding both your eye health and hair loss. If necessary, they can refer you to a dermatologist or a specialist in hair loss for further evaluation and management options.

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