Concerns About Long-Term Use of Medications for Male Pattern Baldness

Boskalis medication consultation?

Hello Dr.
Hsu,
I have been experiencing male pattern baldness, and I have used medications such as Minoxidil, Finasteride, and Dutasteride over the past seven to eight years, switching between them approximately every one to two years.
Currently, I am only taking half a tablet of Dutasteride daily.
I do not feel any discomfort in my body at the moment.

I would like to inquire whether the use of these medications could cause harm to my organs, such as the liver or kidneys.
Are there specific aspects I should be aware of, or particular health checks I should focus on? Additionally, if I plan to conceive, should I discontinue the medication?
Thank you for your guidance on these questions.

Mr. L, 30~39 year old female. Ask Date: 2015/07/23

Dr. Xu Wencang reply Urology

Men taking Proscar or Finasteride theoretically have negligible levels of the drug in their semen and sperm, which should not affect fertility.
Additionally, the development of external genitalia in the embryo occurs during the seventh week, so there should be no impact.
If there are concerns, the drug concentration in the blood will typically be undetectable after 5 to 7 days, and sexual activity should not affect the chances of conception.
There are sporadic reports of liver function impact, and less than 5% may experience sexual dysfunction or decreased libido; please refer to the medication's prescribing information for more details.

Reply Date: 2015/07/23

More Info

Dear Patient,
Thank you for your inquiry regarding the long-term use of medications for male pattern baldness, specifically regarding the potential effects on your health and any necessary precautions you should consider. It’s great to hear that you have not experienced any immediate discomfort while using these medications, but it’s wise to be proactive about your health.

The medications you mentioned—such as Finasteride (often marketed as Propecia or Proscar) and Dutasteride (often marketed as Avodart)—are commonly prescribed for male pattern baldness. They work by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), which is a key factor in hair loss for men. While these medications can be effective, they are not without potential side effects and long-term implications.

Potential Side Effects and Risks
1. Hormonal Changes: Both Finasteride and Dutasteride can lead to hormonal changes, which may result in side effects such as decreased libido, erectile dysfunction, and gynecomastia (breast tissue enlargement). These side effects can persist even after discontinuation of the medication in some cases, a phenomenon often referred to as Post-Finasteride Syndrome.

2. Liver Function: While there is no strong evidence suggesting that Finasteride or Dutasteride causes liver damage, it is always prudent to monitor liver function, especially if you have pre-existing liver conditions or are taking other medications that may affect liver health.

3. Kidney Function: Similarly, while these medications are not directly associated with kidney damage, any long-term medication use warrants regular kidney function tests, particularly if you have risk factors for kidney disease.

4. Mental Health: Some users have reported mood changes, including depression and anxiety, while taking these medications. If you notice any changes in your mental health, it is important to discuss this with your healthcare provider.

Health Monitoring
Given your long-term use of these medications, it would be advisable to have regular health check-ups that include:
- Liver Function Tests: To ensure that your liver is processing these medications without any adverse effects.

- Kidney Function Tests: To monitor your renal health.

- Hormonal Panels: To assess testosterone and DHT levels, especially if you experience any sexual side effects.

- Mental Health Assessment: If you notice any mood changes or psychological symptoms.

Family Planning Considerations
If you are planning to conceive, it is important to discuss this with your healthcare provider. Finasteride and Dutasteride can potentially affect sperm quality and may pose risks to a developing fetus if taken by a woman who is pregnant or trying to conceive. It is generally recommended to discontinue these medications at least a few months prior to attempting conception.

Conclusion
In summary, while medications for male pattern baldness can be effective, it is crucial to remain vigilant about potential side effects and to engage in regular health monitoring. Always consult with your healthcare provider before making any changes to your medication regimen, especially if you are considering family planning. Your health is paramount, and proactive management is key to ensuring your well-being while using these treatments.

Thank you for reaching out, and I hope this information helps clarify your concerns. Please feel free to ask any further questions.

Best regards,
Doctor Q&A Teams

Similar Q&A

Long-Term Use of Finasteride for Male Pattern Baldness: Risks and Side Effects

Hello doctor, I would like to ask about the long-term use of Finasteride for treating male pattern baldness. Could long-term reduction of DHT lead to issues such as decreased muscle mass or a higher-pitched voice, similar to feminization? Additionally, what other problems might a...

Dr. Wu Yuxin reply Dermatology
Approximately 1 in 200 users may experience an impact on sexual function, while the rest are generally unaffected.

Understanding Male Pattern Baldness: Stress, Habits, and Treatment Options

Hello Doctor, I would like to ask if there is a correlation between male pattern baldness and stress or habits. Recently, when I got a haircut, the stylist mentioned that my hairline is slightly receding and suggested that I see a doctor. I visited two clinics for consultation....

Dr. Wu Yuxin reply Dermatology
Male pattern baldness is a hereditary condition, and factors such as stress and lifestyle can exacerbate it, including smoking and lack of sleep. As for treatment, it is difficult to determine without a proper examination of the affected area. If it is causing significant distres...

Understanding Male Pattern Baldness: Medication Effects and Alternatives

Hello, in recent years, I have been experiencing hair loss and visited the hospital. After a blood test, the doctor found that I have iron and zinc deficiencies (ferritin 28, zinc 680), but also noted that my hair loss appears to be genetically linked to androgenetic alopecia. Co...

Dr. Wu Yuxin reply Dermatology
If male pattern baldness is confirmed, a combination of oral medication and topical hair growth solutions will yield the best results.

Is Finasteride Safe for Young Men? Hair Loss Treatment Insights

Hello, doctor. Two years ago, I used finasteride and a hair growth solution (Kailai) to treat male pattern baldness. I took it for about a year before stopping, but recently I've noticed that my hair loss (on both sides of my forehead) and thinning have started to reappear. ...

Dr. Wu Yuxin reply Dermatology
Oral medications for treating male pattern baldness are classified as prescription drugs. If you stop taking the medication, you may need to continue treatment, or if you have concerns about the side effects, it is advisable to discuss this with your physician. I am unable to pro...