Elevated GOT and GPT Levels in Young Children: A Parent's Guide - Pediatrics

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Elevated levels of GOT (Glutamate Oxaloacetate Transaminase) and GPT (Glutamate Pyruvate Transaminase), also known as AST and ALT respectively, can be concerning for parents, especially when observed in young children. These enzymes are primarily found in the liver, and their elevated levels can indicate liver inflammation or damage. However, it is essential to understand the context in which these elevations occur, particularly in the case of your son.

From your description, it appears that your son experienced a viral illness, which is common in young children. Viral infections can lead to transient elevations in liver enzymes, and this is often a benign condition that resolves as the infection subsides. In your son's case, the initial high fever and subsequent symptoms of a sore throat and ear discomfort suggest a viral upper respiratory infection, which is frequently associated with elevated liver enzymes.

The medications your son was prescribed, including MEQUITINE, may have potential side effects, but it is crucial to note that the elevation of liver enzymes can occur independently of medication use, especially in the context of an ongoing viral infection. The liver is quite resilient and can often recover from mild elevations in enzyme levels once the underlying cause, such as a viral infection, is resolved.

Regarding the specific concern about the rising levels of GOT and GPT despite stopping the medications, it is not uncommon for liver enzyme levels to fluctuate during the course of an illness. The liver may take some time to return to baseline levels after an acute insult, even after the symptoms have improved. The fact that your son's white blood cell count returned to normal is a positive sign, indicating that the acute phase of the infection may be resolving.

The gastroenterologist's suggestion that the elevated liver enzymes could be related to the viral infection is plausible. Viral hepatitis, for instance, can cause significant elevations in liver enzymes, but this is typically accompanied by other symptoms such as jaundice (yellowing of the skin and eyes), which you did not mention.
In terms of monitoring your son's condition, it is essential to follow up with your healthcare provider. They may recommend repeat blood tests to monitor the liver enzymes and ensure they are trending downwards. If the levels remain elevated or continue to rise, further investigation may be warranted to rule out other potential causes, such as metabolic disorders or autoimmune conditions.

In summary, while elevated GOT and GPT levels can be concerning, they are often transient and related to underlying infections, particularly in young children. It is crucial to maintain open communication with your healthcare provider, adhere to follow-up appointments, and monitor your son's symptoms closely. If he develops any new symptoms or if you have ongoing concerns, do not hesitate to seek further medical advice. Early intervention can be key in managing any potential issues effectively.