Elevated Blood Uric Acid Levels in Young Children

Q: Elevated Blood Uric Acid Levels in Young Children

Hello： The term "acidemia" refers to a blood pH level of less than 7.4 ± 0.05, primarily due to an excess production of acids in the blood (commonly referring to HCO3) or inadequate elimination by the lungs due to dysfunction or insufficient capacity, leading to the accumulation

Blood uric acid is a waste product formed from the breakdown of purines, which are substances found in certain foods and are also produced by the body. Elevated levels of uric acid in the blood can lead to conditions such

I apologize for the inquiry.
Our child (female) is 2 years and 5 months old, weighing approximately 10.8 kg and measuring about 85 cm in height.
Due to her low weight, blood tests were conducted twice, and the doctor mentioned that her "uric acid" levels were elevated, recommending hospitalization for further examination.
I would like to ask the doctor what uric acid is, what causes it to be elevated, how common it is in children, and what effects it may have on them.
Is hospitalization necessary for thorough testing? Additionally, since I cannot find relevant information, could you please provide sources or websites for further inquiry? Thank you.

Awen, 0~9 year old female. Ask Date: 2004/02/19

Dr. Liang Hongjian reply Pediatrics

Hello: The term "acidemia" refers to a blood pH level of less than 7.4 ± 0.05, primarily due to an excess production of acids in the blood (commonly referring to HCO3) or inadequate elimination by the lungs due to dysfunction or insufficient capacity, leading to the accumulation of acids in the body and resulting in acidosis.
Acidosis can be classified into two types: 1.
Respiratory acidosis and 2.
Metabolic acidosis.
There are many causes for these two types of acidosis, including infections, systemic diseases, metabolic disorders, and neurological conditions.
Today, your doctor has recommended hospitalization to identify the underlying cause.
The aforementioned conditions are not uncommon in children, so once acidemia occurs, it is crucial to determine the cause and initiate treatment.
If left unaddressed, the body will attempt to compensate through respiratory and renal mechanisms; however, inadequate compensation may ultimately lead to respiratory and renal failure.
For more information, you may refer to pediatric departments or databases of major hospitals.
Dr.
Liang Hong-Jian, Department of Pediatrics, Miaoli Hospital.

Reply Date: 2004/02/19

More Info

Elevated blood uric acid levels, also known as hyperuricemia, can be a concerning finding in young children, and your child's situation warrants careful consideration. Uric acid is a waste product formed from the breakdown of purines, which are substances found in many foods and are also produced by the body. Normally, uric acid is dissolved in the blood and eliminated from the body through the kidneys in urine. However, when the body produces too much uric acid or the kidneys do not excrete enough, levels can rise, leading to hyperuricemia.

In children, elevated uric acid levels can be caused by several factors. These include:
1. Dietary Factors: High intake of purine-rich foods, such as certain meats, seafood, and sugary beverages, can contribute to increased uric acid levels. However, in young children, dietary causes are less common compared to adults.

2. Dehydration: Insufficient fluid intake can lead to concentrated uric acid levels in the blood. Ensuring that your child is well-hydrated is essential.

3. Genetic Factors: Some children may have a genetic predisposition to produce more uric acid or to have less efficient kidney function, which can lead to elevated levels.

4. Metabolic Disorders: Certain metabolic conditions, such as Lesch-Nyhan syndrome or other inherited disorders, can lead to increased uric acid production.

5. Kidney Function: If the kidneys are not functioning properly, they may not be able to excrete uric acid effectively, leading to elevated levels.

6. Obesity: Although your child is underweight, in general, obesity can be a risk factor for elevated uric acid levels due to increased production and decreased excretion.

Regarding the prevalence of elevated uric acid levels in children, it is relatively uncommon compared to adults, but it can occur, especially in the context of the factors mentioned above. The potential impact of elevated uric acid levels in children can vary. While many children with elevated levels may not experience symptoms, hyperuricemia can lead to conditions such as gout or kidney stones in the long term if not addressed.

The recommendation for hospitalization and further testing is likely aimed at determining the underlying cause of the elevated uric acid levels. This may involve additional blood tests, urine tests, and possibly imaging studies to assess kidney function and rule out any metabolic disorders. It is crucial to identify the cause to provide appropriate treatment and management.

In terms of treatment, if the elevated uric acid levels are confirmed, the management may include dietary modifications, increased hydration, and possibly medications to help lower uric acid levels if necessary. It is essential to work closely with your child's healthcare provider to monitor her condition and make informed decisions about her health.

For further information, you may consider reputable medical websites such as the American Academy of Pediatrics (AAP) or the National Kidney Foundation, which provide resources on children's health and conditions related to uric acid levels. Always consult with your child's healthcare provider for personalized advice and treatment options.

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