Do Klonopin and Lamictal Cause Weight Gain? - Pharmacology

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"Keppra" and "Depakote"


Will taking "Ke Dian Ping" (Clonazepam) and "Fan Duo Shan" (Venlafaxine) cause weight gain?

audrey, 10~19 year old female. Ask Date: 2015/08/27

Dr. Liu Huiya reply Pharmacology


Hello: "Clonazepam" and "Fluoxetine" are two medications that belong to the categories of sedatives and antidepressants, respectively.
According to the package insert approved by the Ministry of Health and Welfare, there have been no reports of significant weight gain associated with these medications.
If, due to medication, your daily routine becomes more regular, your mood improves, and your appetite returns to normal, resulting in a slight weight increase, this should be considered a normal phenomenon, and there is no need for concern.

Reply Date: 2015/08/27

More Info


When considering the potential for weight gain associated with the medications Klonopin (clonazepam) and Lamictal (lamotrigine), it's important to understand how each of these medications works and their known side effects.

Klonopin is a benzodiazepine primarily used to treat anxiety disorders and seizures. While weight gain is not a commonly reported side effect of Klonopin, some individuals may experience changes in appetite or metabolism that could indirectly lead to weight changes. Benzodiazepines can sometimes cause sedation, which may lead to a more sedentary lifestyle. If a person becomes less active, this could contribute to weight gain over time, even if their appetite does not significantly increase.

On the other hand, Lamictal is an anticonvulsant medication that is also used as a mood stabilizer in the treatment of bipolar disorder. Lamotrigine is generally considered weight-neutral, meaning it does not typically cause weight gain or loss. In fact, some studies suggest that it may even help with weight management in certain patients, particularly those who have gained weight on other mood stabilizers.

However, individual responses to medications can vary widely. Some patients may experience weight gain while taking these medications due to a variety of factors, including changes in lifestyle, diet, or the underlying condition being treated. For instance, if a person is experiencing improved mood or reduced anxiety due to medication, they may find themselves more inclined to eat or engage in social activities that involve food, which could lead to weight gain.

It is also essential to consider that weight changes can be influenced by many factors beyond medication, including diet, exercise, hormonal changes, and psychological factors. If you have noticed a significant weight change after starting these medications, it is crucial to discuss this with your healthcare provider. They can help determine whether the medications are contributing to your weight changes or if other factors may be at play.

In summary, while Klonopin and Lamictal are not typically associated with weight gain, individual experiences can vary. If you are concerned about weight changes while on these medications, it is advisable to consult your doctor. They may suggest lifestyle modifications, dietary changes, or even adjustments to your medication regimen if necessary. Maintaining open communication with your healthcare provider is key to managing both your mental health and any side effects you may experience from your medications.

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