HPV: Vaccine Efficacy and Recurrence Concerns - Dermatology

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Questions regarding HPV?


Dear Dr.
Wu,
I have an HPV infection in my rectum and anus, and although I am receiving treatment, I frequently experience recurrences.
I would like to ask you a few questions based on what I found online regarding the HPV vaccine, which is said to be unable to cure HPV.
1.
If I remove the lesions and then receive the HPV vaccine, will it effectively reduce the likelihood of recurrence?
2.
Does the HPV vaccine start producing antibodies after the first dose, or is it only effective after completing all three doses? (Specifically, can the first dose help reduce the recurrence rate?)
3.
Is the HPV vaccine effective against the virus in the rectum and anus as well? I read online that the vaccine may not provide as much protection for certain areas in males.
Thank you.

Xiu, 20~29 year old female. Ask Date: 2015/09/17

Dr. Wu Yuxin reply Dermatology


1.
The vaccine only targets a limited number of specific viruses that can cause cervical cancer, so it does not reduce the recurrence rate.
2.
Complete vaccination provides better protection.
3.
The main issue is still the viral strains.

Reply Date: 2015/09/17

More Info


Dear Patient,
Thank you for your questions regarding HPV and the HPV vaccine. It’s understandable to have concerns, especially when dealing with recurrent infections. Let’s address your queries one by one.

1. Can the HPV vaccine reduce the recurrence rate after removing lesions?
The HPV vaccine is designed to protect against certain high-risk types of HPV that are known to cause cervical cancer and other HPV-related diseases. While the vaccine cannot cure existing HPV infections or lesions, it can help prevent future infections from the types of HPV covered by the vaccine. If you have successfully removed the lesions and are vaccinated, you may reduce the risk of future infections from the specific HPV types included in the vaccine. However, it’s important to note that the vaccine does not provide protection against all HPV types, so it may not eliminate the risk of recurrence entirely.

2. When does the HPV vaccine start to provide immunity?
The HPV vaccine typically requires a series of three doses to achieve optimal protection. While some immune response may begin after the first dose, full protective immunity is generally established after completing all three doses. Therefore, while the first dose may provide some level of protection, it is not sufficient to rely on it alone for preventing recurrence. It is crucial to complete the vaccination series to ensure the best possible immune response against the targeted HPV types.

3. Is the HPV vaccine effective against anal and rectal HPV infections?
Yes, the HPV vaccine is effective against anal and rectal HPV infections, particularly for the high-risk types that are associated with anal cancer. The vaccine has been shown to provide protection against HPV-related diseases in both males and females, including those affecting the anal region. However, it is essential to understand that the vaccine is most effective when administered before the onset of sexual activity, as it does not treat existing infections or diseases.

Regarding your concern about the effectiveness of the vaccine in males, it is true that some studies suggest that the vaccine may have slightly lower efficacy in preventing certain HPV-related diseases in males compared to females. However, the vaccine still provides significant protection against the types of HPV that can lead to anal and genital cancers, as well as genital warts.

In summary, while the HPV vaccine cannot cure existing infections or lesions, it can help prevent future infections from the types of HPV it covers. Completing the vaccination series is essential for achieving the best protective effect. If you have further concerns or specific health conditions, I recommend discussing them with your healthcare provider, who can provide personalized advice based on your medical history and current health status.

Best wishes for your health and well-being.

Sincerely,
Doctor Q&A Teams


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