Impact of Steroid Use During Early Pregnancy: What You Need to Know - Obstetrics and Gynecology

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Unaware of being pregnant, I took antihistamines containing steroids for a month and received a steroid injection?


Hello doctor, my last menstrual period was on September 27, and I am currently 5 weeks pregnant.
I was unaware of my pregnancy and experienced a recurrence of chronic urticaria throughout September, so I took 2 tablets of antihistamine medication, twice to three times a day, without any effectiveness.
On October 5, I received an injection, and the doctor said it was a corticosteroid.
In total, I received one corticosteroid injection and four allergy shots within half a month, and the doctor mentioned that the medications also contained corticosteroids.
I can confirm that conception occurred on October 11.
I would like to know if this will affect the fetus.

ada, 30~39 year old female. Ask Date: 2015/10/31

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, corticosteroids and antihistamine injections are generally classified around Category C, which indicates minimal risk.
As for the specific components of the medication "敏肝寧" (Min Gan Ning), I'm not very familiar with it.
However, if you have further concerns, it would be advisable to consult your regular obstetrician-gynecologist.
Wishing you good health!

Reply Date: 2015/10/31

More Info


The use of steroids during early pregnancy is a topic of significant concern for many expectant mothers. In your case, you mentioned that you have been using a steroid for chronic urticaria (hives) and received multiple injections, including steroids, before realizing you were pregnant. It’s understandable to be worried about the potential impact on your developing fetus.

Firstly, it’s important to classify the type of steroids you have been using. Corticosteroids, which are commonly prescribed for conditions like allergies and inflammation, are categorized into different classes based on their potential effects during pregnancy. The FDA classifies medications into categories A, B, C, D, and X, with A being the safest and X being contraindicated in pregnancy. Most corticosteroids fall into category C, which means that while animal studies may show adverse effects, there are no adequate studies in pregnant women. This indicates that the potential benefits of using the medication may outweigh the risks, but caution is advised.

In your specific case, the use of steroids in the early weeks of pregnancy, particularly before you were aware of your pregnancy, raises valid concerns. The first trimester is a critical period for fetal development, and exposure to certain medications can potentially lead to complications. However, the risk associated with short-term steroid use, especially in low doses, is generally considered to be low. Most studies suggest that the occasional use of corticosteroids does not significantly increase the risk of major congenital malformations or adverse pregnancy outcomes.

That said, chronic use of high doses of steroids can lead to complications such as intrauterine growth restriction or preterm birth, but these risks are typically associated with long-term therapy rather than short-term use. Given that you received a steroid injection and took oral steroids for a limited time, the likelihood of significant adverse effects is reduced.

It’s also important to consider the underlying condition for which you were treated. Chronic urticaria can cause significant discomfort and distress, and managing this condition effectively is crucial for your overall well-being during pregnancy. If the benefits of controlling your symptoms with steroids outweigh the potential risks to the fetus, your healthcare provider may recommend continuing treatment, albeit with careful monitoring.

In conclusion, while it is understandable to be concerned about the effects of steroid use during early pregnancy, the evidence suggests that short-term, low-dose steroid use is unlikely to cause significant harm to the fetus. However, it is essential to discuss your specific situation with your obstetrician or a maternal-fetal medicine specialist. They can provide personalized advice based on your medical history, the severity of your condition, and the medications you have used. Regular prenatal care and open communication with your healthcare team will help ensure the best possible outcomes for both you and your baby.

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