Managing Conjunctivitis During Pregnancy: Safety of Eye Drops - Ophthalmology

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Pregnancy conjunctivitis


Hello doctor, I am five months pregnant and recently sought medical attention for conjunctivitis.
The doctor prescribed Maxitrol eye drops for me, but they were ineffective.
I then visited another doctor who prescribed Refresh Plus and Bepreve eye drops.
However, both of these seem to be classified as Category C medications, and I am concerned that Bepreve may contain chloramphenicol, which is known to severely inhibit fetal bone marrow development.
Does Bepreve contain chloramphenicol? Are both medications safe to use? Will there be any effects? Thank you.

Jie, 20~29 year old female. Ask Date: 2015/12/03

Dr. Wang Zhishun reply Ophthalmology


Hello, I consulted with an obstetrician-gynecologist, and the response was that these standards are set for systemic medications.
These two types of eye drops should be safe when used correctly in the local area.
After applying the drops, keep your eyes gently closed for at least one to two minutes without immediately opening them or blinking.
At the same time, use your finger to press on the inner corner of the eye, near the nasal bone and lacrimal sac, for one to two minutes to prevent the drops from flowing into the oral cavity through the nasolacrimal duct, which could lead to systemic absorption.

Reply Date: 2015/12/03

More Info


Managing conjunctivitis during pregnancy can be a challenging situation, especially when considering the safety of medications for both the mother and the developing fetus. Your concerns about the use of eye drops, particularly those classified as Category C drugs, are valid and warrant careful consideration.

Firstly, it’s important to understand what Category C means in the context of pregnancy. Drugs classified as Category C have shown adverse effects on the fetus in animal studies, but there are no adequate and well-controlled studies in humans. This means that while there may be potential risks, the benefits of using the medication may outweigh those risks in certain situations, particularly when the mother’s health is at stake.

In your case, you mentioned that you were prescribed CROMO EYE DROPS (Cromolyn Sodium), which is typically used for allergic conjunctivitis and is generally considered safe for use during pregnancy. The risk of systemic absorption from topical eye drops is minimal, especially when used as directed. The advice to apply a cold compress and use the drops as needed is a common recommendation for managing symptoms of conjunctivitis.

Regarding the other medications you mentioned, such as復舒寧 (likely referring to a combination of medications) and 必視明 (which may contain Chloramphenicol), it’s crucial to clarify their ingredients. Chloramphenicol is indeed associated with serious side effects, including the potential for bone marrow suppression in the fetus, which is why it is generally avoided during pregnancy unless absolutely necessary. If you are concerned about the presence of Chloramphenicol in the eye drops prescribed, it would be prudent to consult your healthcare provider for clarification. They can provide specific information about the ingredients and their safety profile during pregnancy.

When it comes to managing conjunctivitis during pregnancy, here are some general guidelines:
1. Consult Your Healthcare Provider: Always discuss any medications you are prescribed with your obstetrician or healthcare provider. They can assess the risks and benefits based on your specific situation.

2. Use Medications Judiciously: If a medication is deemed necessary, use it as directed. For topical medications, the absorption into the systemic circulation is usually low, which reduces the risk to the fetus.

3. Monitor Symptoms: Keep track of your symptoms. If the eye drops are not providing relief, inform your healthcare provider. They may suggest alternative treatments or further evaluation.

4. Consider Non-Pharmacological Approaches: In addition to medications, consider using warm compresses, maintaining good eye hygiene, and avoiding allergens or irritants that may exacerbate your symptoms.

5. Follow Up: Regular follow-up with your healthcare provider is essential to monitor both your health and the health of your baby.

In summary, while there are concerns regarding the use of certain medications during pregnancy, many topical eye drops can be used safely under the guidance of a healthcare provider. It’s essential to communicate openly with your doctor about your symptoms and any concerns you have regarding the medications prescribed. They can help you navigate your treatment options while ensuring the safety of both you and your baby.

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