Pregnancy and Eye Medications: Safety Concerns for Acute Conjunctivitis - Ophthalmology

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Ophthalmic Medication Consultation During Pregnancy


Hello, doctor.
I am currently 35 weeks pregnant.
Last night, I experienced a sharp pain in my right eye, and there was continuous discharge.
This morning, I was diagnosed with "acute conjunctivitis." I informed the doctor that I am pregnant at that time.
I was prescribed "Ophthalmic Latanoprost and Timolol Combination" and "Bimatoprost Ointment." After returning home, I did some research and found that both medications have a pregnancy category of C.
I'm unsure whether I can continue using them or if I need to switch to different medications.

Zhou Xiaojie, 20~29 year old female. Ask Date: 2022/12/26

Dr. Gao Pilin reply Ophthalmology


Hello: Generally, when used topically, these two medications rarely affect other parts of the body.
They are classified as Category C, and in the absence of alternative medications, they can still be used.
When applying the drops, try to keep your eyes closed for 3 minutes instead of blinking, as this can reduce the flow of the solution into the nasolacrimal duct and subsequently to the throat, minimizing systemic absorption.

Reply Date: 2022/12/26

More Info


When it comes to the use of eye medications during pregnancy, particularly for conditions like acute conjunctivitis, it is essential to weigh the benefits against potential risks. In your case, you have been prescribed two medications: "眼科用臨得隆複合液" (likely a combination of medications) and "比達爽軟膏" (likely a topical ointment). Both of these medications are classified as Category C drugs in pregnancy.

Category C drugs are those for which animal reproduction studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in humans. This means that while there is some evidence of potential risks, the benefits of using these medications may outweigh the risks, especially when treating a condition that could lead to more significant complications if left untreated.

In general, topical medications, including eye drops and ointments, are absorbed minimally into the systemic circulation. This limited absorption reduces the likelihood of significant effects on the fetus. However, it is always prudent to consult with your healthcare provider regarding any concerns you may have about medication use during pregnancy.

For acute conjunctivitis, it is crucial to treat the condition effectively to prevent complications such as corneal involvement or secondary bacterial infections. The symptoms you are experiencing—pain, discharge, and irritation—indicate that treatment is necessary. If your doctor has assessed that the benefits of using these medications outweigh the potential risks, it is likely safe to proceed with their use.

Additionally, if you have concerns about the specific medications prescribed, you may want to discuss alternative treatments with your doctor. There may be other options available that are considered safer during pregnancy, or your doctor may provide reassurance about the safety of the current medications based on their clinical experience.

It is also important to follow the instructions for using these medications carefully. For instance, when using eye drops, it is recommended to close your eyes for a few minutes after application to minimize systemic absorption. This technique can help reduce the amount of medication that enters the bloodstream and potentially affects the fetus.

In summary, while Category C medications do carry some risks, the limited absorption of topical eye medications and the necessity of treating your acute conjunctivitis suggest that the prescribed treatments may be appropriate. Always maintain open communication with your healthcare provider, and do not hesitate to express any concerns you may have regarding your treatment plan. Your health and the health of your baby are paramount, and your doctor can help guide you through the safest options available.

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