Is It Safe to Use Ibuprofen Piconol and Isopropyl Methylphenol During Pregnancy? - Obstetrics and Gynecology

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Is there any impact on pregnancy from using this topical ointment?


Ingredient 1: Ibuprofen piconol 30mg
Ingredient 2: Isopropyl methylphenol 3mg
Is there any effect? Thank you.

momo, 20~29 year old female. Ask Date: 2015/12/14

Dr. Lin Wenbin reply Obstetrics and Gynecology


The medication leaflet states that you should consult a physician for examination before use.
The following patients must consult with a physician or pharmacist prior to use: (1) those currently receiving treatment from a physician; (2) individuals with a personal or family history of allergic conditions; (3) those with a history of drug allergies; (4) patients with extensive affected areas; (5) those with severe moist or ulcerated lesions; (6) pregnant women, those who may become pregnant, or nursing mothers; (7) children.

Reply Date: 2015/12/14

More Info


When considering the safety of using topical medications during pregnancy, it is essential to evaluate the specific ingredients and their potential effects on both the mother and the developing fetus. In this case, we are looking at two components: Ibuprofen Piconol and Isopropyl Methylphenol.

Ibuprofen Piconol is a derivative of ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID). While ibuprofen is commonly used for pain relief and inflammation, its safety during pregnancy is a topic of concern. The FDA categorizes ibuprofen as a Category C drug during the first and second trimesters, meaning that risk cannot be ruled out. However, it is classified as Category D during the third trimester, indicating that there is evidence of risk to the fetus, particularly concerning potential cardiovascular issues and other complications.
In general, the use of systemic NSAIDs like ibuprofen is discouraged during pregnancy, especially in the later stages, due to the risk of premature closure of the ductus arteriosus, a vital blood vessel in the fetal heart. However, topical formulations may have a lower systemic absorption compared to oral forms, which could potentially reduce the risk. Nonetheless, caution is advised, and it is crucial to consult with a healthcare provider before using any topical medication containing ibuprofen during pregnancy.

Isopropyl Methylphenol, also known as IPMP, is an antiseptic agent often used in topical formulations. While there is limited data on its safety during pregnancy, it is generally considered to have low systemic absorption when applied topically. However, as with any medication, the lack of extensive studies means that its safety profile during pregnancy is not fully established.
Given these considerations, the use of a topical medication containing both Ibuprofen Piconol and Isopropyl Methylphenol during pregnancy should be approached with caution. It is advisable to consult with a healthcare provider who can assess the specific circumstances, including the reason for using the medication, the potential benefits, and any associated risks.
In summary, while topical medications may present a lower risk than their oral counterparts, the presence of ibuprofen in any form raises concerns, particularly during the later stages of pregnancy. Always prioritize open communication with healthcare providers regarding any medications during pregnancy to ensure the safety of both the mother and the developing fetus. If you have already used the medication, it is essential to inform your healthcare provider to monitor for any potential effects and to discuss alternative treatments if necessary.

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