Effects of Pre-Exposure Medication on Vomiting: Key Concerns and Solutions - Obstetrics and Gynecology

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Vomiting after taking pre-exposure prophylaxis (PrEP)?


Hello, doctor: I usually take the emergency contraceptive pill, Ella (Ulipristal Acetate), around 9-10 PM.
At around 2 AM, I felt hungry and ate noodles and seaweed.
Later, I felt discomfort in my stomach and took an antacid, but after a while, around 2:30 AM, I experienced vomiting.
The vomit had the color of the antacid and some seaweed, but I did not vomit the noodles.

1.
Is the emergency contraceptive pill still effective after this incident?
2.
Since this happened a few days ago, do I need to take another dose?
3.
If I use condoms consistently during any sexual activity moving forward, will this reduce the likelihood of pregnancy?

Nìmíng, 10~19 year old female. Ask Date: 2015/12/15

Dr. Lü Lizheng reply Obstetrics and Gynecology


1.
The contraceptive pill remains effective, and there is no need to take an additional dose.
2.
It should still provide contraceptive protection as long as the pill is taken consistently, so there is no need to use condoms as an extra precaution.
Sincerely, Dr.
Li-Cheng Lu, Taoyuan Hospital.

Reply Date: 2015/12/15

More Info


When it comes to the effects of pre-exposure medication, particularly in the context of emergency contraception or hormonal contraceptives, there are several important considerations to keep in mind, especially when experiencing symptoms like vomiting.
1. Effectiveness of the Medication After Vomiting: If you vomited within a couple of hours after taking your pre-exposure medication (in this case, the contraceptive), there is a possibility that the medication may not have been fully absorbed into your system. Most hormonal contraceptives need to be absorbed by the gastrointestinal tract to be effective. If vomiting occurs shortly after ingestion, it is advisable to consult with a healthcare provider to determine whether a repeat dose is necessary. Generally, if vomiting occurs within two hours of taking the medication, it is recommended to take another dose.

2. Need for Additional Doses: Since the incident occurred a few days ago, the immediate concern would be whether you need to take an additional dose of the medication. If you are still within the window for emergency contraception (which is typically within 72 to 120 hours after unprotected intercourse, depending on the type of medication), and you suspect that the initial dose was not effective due to vomiting, you should consider taking another dose. However, if you are outside of this window, the effectiveness of the medication diminishes significantly, and you may need to explore other contraceptive options or consult with a healthcare provider for further guidance.

3. Using Condoms for Additional Protection: Using condoms in conjunction with hormonal contraceptives is a good practice to reduce the risk of unintended pregnancy. While hormonal contraceptives are effective when taken correctly, they can be less effective if there are issues with absorption (like vomiting). Therefore, using condoms can provide an additional layer of protection against pregnancy and also protect against sexually transmitted infections (STIs). It is always a good idea to use condoms, especially if there are concerns about the effectiveness of your primary contraceptive method.


Additional Considerations:
- Dietary Factors: Eating certain foods, especially heavy or greasy meals, can sometimes lead to gastrointestinal discomfort, which may exacerbate feelings of nausea or lead to vomiting. It might be beneficial to monitor your diet, especially after taking medication, to see if certain foods trigger discomfort.

- Medication Interactions: If you are taking other medications or supplements, it's important to consider potential interactions that could affect the efficacy of your contraceptive. Always inform your healthcare provider about all medications you are taking.

- Consulting a Healthcare Provider: If vomiting persists or if you experience other concerning symptoms, it is crucial to seek medical advice. A healthcare provider can offer tailored advice based on your specific situation and medical history.

In summary, if you vomited shortly after taking your pre-exposure medication, it is essential to assess whether the medication was absorbed effectively. If you are within the appropriate time frame for emergency contraception and are unsure about the effectiveness of your dose, consider taking another dose and consult with a healthcare provider. Additionally, using condoms can help mitigate the risk of unintended pregnancy and provide extra protection. Always prioritize open communication with your healthcare provider regarding any concerns or symptoms you may experience.

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