Can You Take Lansoprazole Before Bed for Acid Reflux? - Gastroenterology and Hepatology

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Can lansoprazole be taken before bedtime?


Hello, doctor! I would like to ask if lansoprazole, which is used to treat gastroesophageal reflux disease (GERD) and mild esophagitis, can be taken on an empty stomach before bedtime? I noticed that the instructions state to take it one hour before meals or two hours after meals, once a day.
I feel that there might be more stomach acid during sleep and would like to take it before bed.
Thank you for clarifying this for me.

Mr. Li, 30~39 year old female. Ask Date: 2015/12/17

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello Mr.
Li: Yes, I often use it for nighttime reflux (due to lying flat) before bed.
Changhua Hospital cares about your health.
Chen Shidian

Reply Date: 2015/12/17

More Info


Lansoprazole is a proton pump inhibitor (PPI) commonly prescribed for the treatment of gastroesophageal reflux disease (GERD) and other conditions related to excessive stomach acid production. It works by reducing the amount of acid produced in the stomach, which can help alleviate symptoms such as heartburn, regurgitation, and discomfort associated with acid reflux.

Regarding your question about taking lansoprazole before bed, the standard recommendation is to take it on an empty stomach, typically one hour before a meal or two hours after a meal. This timing is crucial because taking lansoprazole with food can reduce its effectiveness. The reason for this is that food can stimulate gastric acid secretion, which may counteract the benefits of the medication.

However, if you are experiencing significant acid reflux symptoms at night, it is understandable that you might want to take lansoprazole before bed. While the official guidelines do not specifically recommend this timing, some healthcare providers may allow for flexibility based on individual patient needs. It is essential to consult with your physician or healthcare provider about your specific situation. They can assess your symptoms and determine whether adjusting the timing of your medication is appropriate for you.

In terms of potential side effects, lansoprazole is generally well-tolerated, but like any medication, it can have adverse effects. Common side effects include headache, diarrhea, constipation, nausea, and abdominal pain. Long-term use of PPIs has been associated with certain risks, such as vitamin B12 deficiency, magnesium deficiency, and an increased risk of gastrointestinal infections. Therefore, it is crucial to use this medication under the guidance of a healthcare professional and to have regular follow-ups to monitor your condition and any potential side effects.

If you decide to take lansoprazole before bed, it is advisable to do so consistently and monitor your symptoms. If you find that your nighttime symptoms improve, it may be a suitable adjustment for you. However, if you experience any adverse effects or if your symptoms do not improve, you should reach out to your healthcare provider for further evaluation and management.

In summary, while the standard recommendation is to take lansoprazole before meals, some patients may benefit from taking it before bed, especially if they experience nighttime acid reflux. Always consult with your healthcare provider before making any changes to your medication regimen to ensure it aligns with your health needs and treatment goals.

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