Persistent Jaundice in Infants: Causes and Concerns - Pediatrics

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The jaundice in the one-month-old infant has not decreased to below the normal range?


Hello, my baby is currently one month and one week old and is partially breastfed.
The jaundice index is still at 2.9.
The body no longer appears yellow, but the face still has a slight yellow tint.
The doctor mentioned that normally, the level should drop below 2 by the time the baby is one month old.
I have tried stopping breastfeeding for 5 days, but the jaundice index remained at 2.8.
What could be the possible reasons for this? Could it be neonatal hepatitis or biliary atresia? The jaundice index was 15.2 a week after birth and has gradually decreased to the current 2.8-2.9, but it has remained stable at this level.
The stool is currently dark green, sometimes with a slight yellow tint, which is quite concerning.
Please help me with this.
Thank you!

Xiao Bai, 30~39 year old female. Ask Date: 2016/01/11

Dr. Pei Rensheng reply Pediatrics


Hello: It is quite common for a one-month-old baby to have a bilirubin level around 2-3 mg/dL.
This is due to the shorter half-life of fetal red blood cells compared to adults, along with factors such as increased enterohepatic circulation, which can result in higher bilirubin levels in infants.
When measuring direct bilirubin, if it exceeds 20%, there may be a possibility of biliary atresia.
Wishing you health and happiness! Sincerely, Dr.
Pei Ren-Sheng, Chief of Pediatrics, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2016/01/11

More Info


Persistent jaundice in infants, particularly when it continues beyond the first month of life, can be a source of concern for parents. In your case, your baby is one month and one week old, and the bilirubin level is at 2.9 mg/dL, which is indeed higher than the expected level for a baby of this age. Typically, jaundice should resolve within the first two weeks of life, and by one month, bilirubin levels should ideally be below 2 mg/dL.
There are several potential causes for persistent jaundice in infants, and it is essential to consider these to understand the situation better. Here are some common causes:
1. Breast Milk Jaundice: This condition can occur in breastfed infants and is usually seen after the first week of life. It is thought to be related to substances in breast milk that can inhibit the liver's ability to process bilirubin. This type of jaundice typically resolves on its own and does not usually indicate a serious problem.

2. Hepatitis or Liver Disease: Conditions such as neonatal hepatitis or other liver diseases can cause prolonged jaundice. If there are signs of liver dysfunction, such as pale stools or dark urine, further investigation is warranted.

3. Biliary Atresia: This is a serious condition where the bile ducts are blocked or absent, preventing bile from draining from the liver. It usually presents with jaundice that persists beyond the first few weeks of life and is often accompanied by pale stools and dark urine. This condition requires prompt diagnosis and treatment.

4. Hemolytic Disease: Conditions such as Rh or ABO incompatibility can lead to increased breakdown of red blood cells, resulting in elevated bilirubin levels. This is usually evident shortly after birth but can persist if there are underlying issues.

5. Infections: Certain infections can also lead to jaundice in newborns, and these should be ruled out if there are other concerning symptoms.

Given that your baby's bilirubin levels have not significantly decreased despite stopping breastfeeding for five days, it is essential to follow up with your pediatrician for further evaluation. They may recommend additional tests, such as liver function tests, a complete blood count, and possibly imaging studies like an abdominal ultrasound to assess the liver and biliary system.

The fact that your baby's stools are currently dark green with some yellow is generally a good sign, as it indicates that bile is being produced and reaching the intestines. However, the persistence of jaundice and the bilirubin levels should be closely monitored.

In summary, while some cases of persistent jaundice are benign and related to breastfeeding, it is crucial to rule out more serious conditions such as biliary atresia or liver disease. Regular follow-up with your healthcare provider is essential to ensure your baby's health and address any concerns you may have. If you notice any additional symptoms, such as changes in stool color, feeding difficulties, or signs of illness, do not hesitate to seek medical attention promptly.

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