Safe Diaper Cream Options for Babies with Favism - Pediatrics

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Diaper rash cream suitable for babies with G6PD deficiency?


My child is currently 6 months old and has G6PD deficiency.
We are aware that there are certain foods and medications that should be avoided, but I would like to ask the doctor: do we also need to be particularly cautious with topical lotions? Recently, my child developed severe diarrhea due to antibiotic use, resulting in a red rash on the bottom.
A friend recommended Desitin Maximum Strength Original Paste: Zinc Oxide Paste from the U.S., but since the labeling is all in English, I am unsure if it is safe to use.
The ingredients listed on the English website include: Zinc Oxide (40%), BHA, Cod liver oil, Fragrance, Lanolin, Methylparaben, Petrolatum, Talc, Water.
Could the doctor please check if this product is safe for a baby with G6PD deficiency? Thank you!

Guo Xiaojie, 30~39 year old female. Ask Date: 2016/01/12

Dr. Xiao Kaiwen reply Pediatrics


This ointment contains fragrance components, but the main ingredients are unclear.
Some of the fragrances may contain substances unsuitable for individuals with Favism, such as Camphor, Methyl Salicylate, and Menthol.
Therefore, I recommend that it should not be used on individuals with Favism.

Reply Date: 2016/01/12

More Info


When it comes to choosing safe diaper creams or lotions for babies with G6PD deficiency (also known as Favism), it is crucial to be cautious about the ingredients used in these products. G6PD deficiency can lead to hemolytic anemia when exposed to certain substances, including specific medications, foods, and even some topical products.
In the case of the Desitin Maximum Strength Original Paste, the primary active ingredient is Zinc Oxide, which is generally considered safe for use in infants, including those with G6PD deficiency. Zinc oxide is a common ingredient in diaper creams due to its protective and soothing properties, helping to create a barrier against moisture and irritants that can cause diaper rash.
However, the formulation also includes several other ingredients that warrant attention:
1. BHA (Butylated Hydroxyanisole): This is a synthetic antioxidant used as a preservative. While it is generally recognized as safe in low concentrations, some individuals may have sensitivities or allergies to it. There is no specific evidence linking BHA to hemolytic reactions in G6PD-deficient individuals, but caution is always advised.

2. Cod Liver Oil: This ingredient is rich in omega-3 fatty acids and vitamins A and D. While it is not known to pose a risk for G6PD deficiency, it is important to ensure that your child does not have any allergies to fish products.

3. Fragrance: Fragrances can be a source of irritation or allergic reactions, especially in sensitive skin. While not directly linked to G6PD deficiency, it is advisable to use fragrance-free products whenever possible to minimize the risk of skin irritation.

4. Lanolin: This is a natural substance derived from sheep's wool and is often used for its moisturizing properties. Lanolin is generally safe, but some individuals may have allergies to it.

5. Methylparaben: This is a preservative used to prevent microbial growth. While it is considered safe in low concentrations, some parents prefer to avoid parabens due to concerns about potential hormonal effects.

6. Petrolatum: This is a common occlusive agent that helps to lock in moisture. It is generally safe for use in infants.

7. Talc: This ingredient is used for its absorbent properties. However, there have been concerns regarding the inhalation of talc, especially in powder form, so it is best to use it cautiously.

8. Water: This is a standard ingredient in many formulations and poses no risk.

Given the ingredients listed, the Desitin Maximum Strength Original Paste may be used cautiously for a baby with G6PD deficiency, but it is essential to monitor for any signs of irritation or allergic reactions. If your child has particularly sensitive skin or has previously reacted to any of these ingredients, it may be best to consult with a pediatrician or dermatologist before use.

In general, when selecting diaper creams for babies with G6PD deficiency, it is advisable to:
- Choose products with minimal and well-known ingredients.

- Avoid products with potential allergens or irritants, such as fragrances and certain preservatives.

- Opt for formulations specifically designed for sensitive skin or labeled as hypoallergenic.

Additionally, maintaining good diaper hygiene—frequent changes, gentle cleaning, and allowing the skin to air out—can significantly help prevent diaper rash and the need for topical treatments. If diaper rash persists or worsens, consulting a healthcare provider is recommended to explore other treatment options that are safe for your child.

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