Treatment Decisions After Conflicting Breast Cancer Diagnoses - Breast and Thyroid

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Dear Doctor: A 1 cm tumor in the breast was evaluated with ultrasound-guided core needle biopsy, which resulted in a diagnosis of carcinoma in situ.
However, the surgical report after the operation indicated a benign finding.
Should the subsequent treatment be based on the biopsy results and proceed with radiation therapy, or should we follow the surgical report and forgo further treatment?

Ms. Li, 40~49 year old female. Ask Date: 2016/01/16

Dr. Zhou Jiazhen reply Breast and Thyroid


Dear Ms.
Li: Based on the pathological report following the surgical resection, if the final pathological report of the entire tumor is benign, then follow-up is sufficient.

Reply Date: 2016/01/16

More Info


When faced with conflicting diagnoses in breast cancer, particularly when a needle biopsy indicates ductal carcinoma in situ (DCIS) but the surgical pathology report shows benign results, it can be quite perplexing. The decision on how to proceed with treatment should be carefully considered, taking into account several factors, including the nature of the initial diagnosis, the findings from the surgical pathology, and the overall clinical context.

1. Understanding the Initial Diagnosis: The initial diagnosis of DCIS from the ultrasound-guided core needle biopsy suggests the presence of abnormal cells within the ducts of the breast that have not invaded surrounding tissues. This condition is often treated as a precursor to invasive breast cancer, and treatment typically involves surgery, which may be followed by radiation therapy, especially if the tumor is of significant size or if there are other risk factors.

2. Surgical Pathology Findings: The surgical pathology report indicating benign results raises questions about the accuracy of the initial biopsy. It is essential to understand that needle biopsies can sometimes yield false-positive results, particularly in cases where the sample may not fully represent the tumor. The surgical specimen, being larger and more comprehensive, provides a more definitive assessment of the tissue.

3. Clinical Decision-Making: Given the conflicting results, it is crucial to have a thorough discussion with your healthcare team, including your surgeon and oncologist. They will consider the following:
- Histological Review: It may be beneficial to have a second opinion on the pathology reports from another pathologist, especially if there is significant doubt about the diagnosis.

- Risk Assessment: Your healthcare team will evaluate your overall risk factors for breast cancer, including family history, genetic predispositions, and any other personal health factors.

- Treatment Options: If the surgical pathology confirms benign findings, it may be reasonable to forego further treatment such as radiation therapy. However, if there is still concern about the initial diagnosis, your team may recommend close monitoring or additional treatments.

4. Follow-Up Care: Regardless of the decision made, ongoing follow-up care is essential. This may include regular mammograms, clinical breast exams, and possibly MRI scans, depending on your individual risk factors and the recommendations of your healthcare team.

5. Patient Empowerment: As a patient, it is important to advocate for your health. Do not hesitate to ask questions, seek clarity on your diagnosis, and express any concerns you may have about the proposed treatment plan. It is your right to understand the rationale behind treatment decisions and to be involved in the decision-making process.

In conclusion, the conflicting results of your breast cancer diagnosis necessitate a careful and collaborative approach to treatment decisions. Engaging in open communication with your healthcare providers, considering second opinions, and evaluating your individual risk factors will guide you in making informed choices about your health. Remember, the goal is to ensure that you receive the most appropriate and effective care tailored to your specific situation.

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