Migratory Numbness and Tingling: Possible Causes and Insights - Neurology

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Widespread tingling, numbness, and occasional brief muscle twitching?


Hello Dr.
Lan! I recently visited the hospital due to unilateral numbness in my limbs and lips.
An MRI revealed symptoms of moderate to severe stenosis of the middle cerebral artery.
I am currently on antiplatelet and lipid-lowering medications.
However, since my discharge a month ago, I have been experiencing migratory numbness throughout my body (sometimes in my hands, feet, scalp, eyes, lips, soles, and back, affecting both sides).
This is accompanied by tingling sensations and occasional brief muscle twitching in my fingers or arms.
My neurologist mentioned that this may not be related to the original cerebrovascular issue and suggested it might be a different problem.
They prescribed medication to improve peripheral blood circulation, but it has not been effective.
I would like to ask Dr.
Lan what possible symptoms could be associated with this migratory numbness and tingling sensation.
Thank you!

Tiānkōng, 40~49 year old female. Ask Date: 2016/01/17

Dr. Lan Shengxing reply Neurology


Due to its systemic nature, it may be necessary to first consider factors affecting the entire body, such as metabolism, toxins, medications, and immune responses, which can present symptoms similar to neuropathic pain.
It may be necessary to arrange for nerve conduction studies and laboratory data used for diagnosing the aforementioned conditions for a comprehensive evaluation.

Reply Date: 2016/01/17

More Info


Migratory numbness and tingling, especially when it presents in various parts of the body, can be concerning and may indicate a range of underlying conditions. Given your recent history of unilateral numbness and the discovery of significant cerebral artery stenosis, it is understandable that you are seeking clarity on your current symptoms.

Firstly, it's important to recognize that numbness and tingling (paresthesia) can arise from numerous causes, including neurological, vascular, metabolic, and even psychological factors. In your case, the fact that you have experienced these sensations migrating across different body parts suggests a possible systemic issue rather than a localized problem.

1. Peripheral Neuropathy: This is one of the most common causes of numbness and tingling. It can result from diabetes, vitamin deficiencies (especially B12), alcohol use, or exposure to toxins. Peripheral neuropathy often presents with symptoms in the hands and feet, but can also affect other areas.

2. Multiple Sclerosis (MS): MS is a demyelinating disease that can cause a wide range of neurological symptoms, including migratory numbness and tingling. It often presents with episodes of neurological deficits that can resolve, only to return later in different forms.

3. Cervical or Lumbar Radiculopathy: Compression of nerve roots in the cervical or lumbar spine can lead to symptoms that radiate to different parts of the body. This can be due to herniated discs, spinal stenosis, or other degenerative changes.

4. Vascular Issues: While your neurologist suggested that your current symptoms are unrelated to your cerebral artery condition, it is still worth considering that vascular insufficiencies elsewhere in the body could contribute to your symptoms. Conditions like Raynaud's phenomenon or peripheral artery disease could lead to intermittent numbness and tingling.

5. Anxiety and Stress: Psychological factors can also manifest as physical symptoms. Anxiety can lead to hyperventilation, which may cause temporary numbness and tingling in the extremities and face. Stress can exacerbate existing conditions, leading to increased awareness of bodily sensations.

6. Autoimmune Disorders: Conditions such as lupus or rheumatoid arthritis can affect the nervous system and lead to symptoms like yours. These disorders can cause inflammation that impacts nerve function.

7. Medication Side Effects: Since you are on antiplatelet and lipid-lowering medications, it is essential to consider whether these could be contributing to your symptoms. Some medications can lead to peripheral neuropathy or other neurological side effects.

Given the complexity of your symptoms and their potential causes, it is crucial to continue working closely with your healthcare provider. A thorough evaluation, including blood tests to check for vitamin deficiencies, autoimmune markers, and possibly further imaging studies, may be warranted. Additionally, a referral to a neurologist specializing in peripheral nerve disorders could provide further insights.

In summary, while your current symptoms may not be directly related to your previous cerebrovascular condition, they warrant careful investigation. Migratory numbness and tingling can arise from various conditions, and a comprehensive approach to diagnosis and treatment is essential for effective management. Please ensure you communicate all your symptoms and concerns with your healthcare provider to facilitate a thorough evaluation and appropriate care.

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