The function of PRP (Platelet-Rich Plasma) in relation to the anterior cruciate ligament (ACL)?
Hello Dr.
Shi, I am a patient with a torn anterior cruciate ligament (ACL) that occurred about a year and a half ago.
The injury happened during my first skiing experience when I fell, and then again when I lost my footing and fell down six or seven steps, severely twisting my knee.
At that time, my knee was extremely swollen.
Now, I feel that my knee is unstable, and after standing for about 15 minutes, my legs feel weak.
I have undergone an MRI at the hospital, which indicated: "Partial tear of the anterior cruciate ligament with attenuated ligamentous fibers at the distal portion of the ligament." The doctor mentioned that surgery was not necessary at that time.
However, after a year of rehabilitation training, my knee still feels unstable and does not meet my daily living needs, often leading to weakness in my legs.
Recently, I have seen a lot about the use of PRP (platelet-rich plasma) therapy, which seems to be effective for knee issues, but each treatment session costs over ten thousand, which is a financial burden.
I would like to ask Dr.
Shi why a torn ACL does not heal on its own.
Is it because there is insufficient blood supply to that ligament? How should I understand the benefits of PRP for the ACL? I found only one article online stating that "PRP shows little benefit in ACL reconstruction at 6 months" (http://www.aaos.org/AAOSNow/2010/Apr/clinical/clinical3/?ssopc=1), but it seems to suggest that it has some effect for those who have undergone surgery.
What is the actual efficacy of PRP for someone like me who has not had surgical reconstruction? Thank you!
Xiao Wen, 20~29 year old female. Ask Date: 2016/01/29
Dr. Shi Guozheng reply Orthopedics
PRP has a certain effect on ligament repair; however, if the anterior cruciate ligament (ACL) has already become lax after an injury, there may still be laxity even after healing, which diminishes its effectiveness.
According to this study, injecting PRP after ligament reconstruction surgery has little impact.
Therefore, I recommend that you focus on rehabilitation to strengthen your thigh muscle strength to compensate for the ligament instability.
Unless there are functional impairments, surgery can be temporarily avoided.
Reply Date: 2016/01/29
More Info
Platelet-Rich Plasma (PRP) therapy has gained attention in recent years as a potential treatment for various musculoskeletal injuries, including those involving the anterior cruciate ligament (ACL). Understanding the role of PRP in ACL injuries, particularly in cases of partial tears, is essential for patients seeking effective treatment options.
Firstly, it is important to understand the nature of ACL injuries. The ACL is a critical ligament in the knee that provides stability, particularly during activities that involve sudden stops or changes in direction, such as skiing or descending stairs. When the ACL is partially torn, as indicated in your MRI report, the ligament's fibers are damaged but not completely severed. This can lead to instability in the knee, causing symptoms such as swelling, a feeling of looseness, and difficulty bearing weight.
One of the primary reasons why a torn ACL does not heal on its own is due to its relatively poor blood supply. Unlike other tissues in the body that have a rich vascular network, the ACL has limited blood flow, which is crucial for healing. This lack of blood supply means that the healing process is slower and less effective, which is why many patients experience ongoing instability and discomfort even after conservative treatments like physical therapy.
PRP therapy aims to address this issue by utilizing the body's own healing mechanisms. PRP is derived from the patient's own blood, which is processed to concentrate the platelets. These platelets contain growth factors that can promote healing and tissue regeneration. When injected into the site of injury, PRP is thought to enhance the healing process by increasing the local concentration of these growth factors, potentially leading to improved outcomes.
However, the effectiveness of PRP for ACL injuries, particularly for partial tears, remains a topic of debate in the medical community. Some studies suggest that PRP may provide benefits in terms of pain relief and functional improvement, while others indicate that its impact on actual healing of the ligament is limited. For instance, the article you referenced suggests that PRP shows little benefit in ACL reconstruction at six months, which raises questions about its efficacy in non-surgical cases.
For individuals like yourself, who have not undergone surgical reconstruction, the potential benefits of PRP may still be relevant. While PRP may not fully restore the ligament to its original state, it could potentially aid in reducing pain and improving function, making it easier to engage in daily activities. However, it is crucial to have realistic expectations. PRP is not a guaranteed solution, and its effectiveness can vary from person to person.
In terms of cost, PRP therapy can indeed be expensive, and it is essential to weigh the potential benefits against the financial burden. Consulting with your healthcare provider about the expected outcomes and any alternative treatments is advisable. They can help you make an informed decision based on your specific condition and treatment goals.
In conclusion, while PRP therapy may offer some benefits for individuals with partial ACL tears, its effectiveness is not universally established. The unique nature of your injury, combined with the limitations of the ACL's healing capacity, means that a comprehensive approach—including physical therapy, lifestyle modifications, and possibly PRP—may be the best course of action. Always consult with a qualified healthcare professional to determine the most appropriate treatment plan for your specific situation.
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